(data stored in ACNUC7421 zone)

SWISSPROT: HIS4_RHOPS

ID   HIS4_RHOPS              Reviewed;         245 AA.
AC   Q13E39;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   08-MAY-2019, entry version 68.
DE   RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase {ECO:0000255|HAMAP-Rule:MF_01014};
DE            EC=5.3.1.16 {ECO:0000255|HAMAP-Rule:MF_01014};
DE   AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase {ECO:0000255|HAMAP-Rule:MF_01014};
GN   Name=hisA {ECO:0000255|HAMAP-Rule:MF_01014};
GN   OrderedLocusNames=RPD_0412;
OS   Rhodopseudomonas palustris (strain BisB5).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BisB5;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Pelletier D.A., Kyrpides N.,
RA   Lykidis A., Oda Y., Harwood C.S., Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris BisB5.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-
CC         ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-
CC         phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-
CC         beta-D-ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:15469,
CC         ChEBI:CHEBI:58435, ChEBI:CHEBI:58525; EC=5.3.1.16;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01014};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC       {ECO:0000255|HAMAP-Rule:MF_01014}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01014}.
CC   -!- SIMILARITY: Belongs to the HisA/HisF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01014}.
DR   EMBL; CP000283; ABE37650.1; -; Genomic_DNA.
DR   RefSeq; WP_011500838.1; NC_007958.1.
DR   SMR; Q13E39; -.
DR   STRING; 316057.RPD_0412; -.
DR   EnsemblBacteria; ABE37650; ABE37650; RPD_0412.
DR   KEGG; rpd:RPD_0412; -.
DR   eggNOG; ENOG4105CJV; Bacteria.
DR   eggNOG; COG0106; LUCA.
DR   HOGENOM; HOG000224614; -.
DR   KO; K01814; -.
DR   OMA; EWLHLVD; -.
DR   OrthoDB; 794219at2; -.
DR   BioCyc; RPAL316057:RPD_RS02120-MONOMER; -.
DR   UniPathway; UPA00031; UER00009.
DR   Proteomes; UP000001818; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04732; HisA; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01014; HisA; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006062; His_biosynth.
DR   InterPro; IPR006063; HisA.
DR   InterPro; IPR023016; Isoase_HisA.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00977; His_biosynth; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   TIGRFAMs; TIGR00007; TIGR00007; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13E39.
DR   SWISS-2DPAGE; Q13E39.
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Isomerase.
FT   CHAIN         1    245       1-(5-phosphoribosyl)-5-[(5-
FT                                phosphoribosylamino)methylideneamino]
FT                                imidazole-4-carboxamide isomerase.
FT                                /FTId=PRO_0000290526.
FT   ACT_SITE      8      8       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_01014}.
FT   ACT_SITE    129    129       Proton donor. {ECO:0000255|HAMAP-
FT                                Rule:MF_01014}.
SQ   SEQUENCE   245 AA;  25553 MW;  A9257BF91281EE9D CRC64;
     MILFPAIDLK NGQCVRLEQG DMARATVFNL DPAAQARSFA AQGFQYLHVV DLDGAFAGKP
     VNAQAVESML KVVSMPVQLG GGIRDLKTVE GWLAKGISRV IIGTAAVRDP ALVKQAAKKF
     PGRVAVGLDA RDGKVAVEGW AESSQVTALE IAQRFEDAGV AAIIFTDIAR DGLLKGINWE
     ATIALAEAVS IPVIASGGLA SIDDVKALLS PRANKLEGAI AGRALYDGRL DPAEALALID
     AARAA
//

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