(data stored in ACNUC9543 zone)

SWISSPROT: KUP_YERPA

ID   KUP_YERPA               Reviewed;         622 AA.
AC   Q1CC44;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   08-MAY-2019, entry version 69.
DE   RecName: Full=Low affinity potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
DE   AltName: Full=Kup system potassium uptake protein {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   OrderedLocusNames=YPA_0009;
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua;
RX   PubMed=16740952; DOI=10.1128/JB.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F.,
RA   Vergez L.M., Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and
RT   Nepal516: evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- FUNCTION: Responsible for the low-affinity transport of potassium
CC       into the cell, with the probable concomitant uptake of protons
CC       (symport system). {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
DR   EMBL; CP000308; ABG11978.1; -; Genomic_DNA.
DR   RefSeq; WP_002212253.1; NZ_CP009906.1.
DR   EnsemblBacteria; ABG11978; ABG11978; YPA_0009.
DR   KEGG; ypa:YPA_0009; -.
DR   HOGENOM; HOG000218033; -.
DR   KO; K03549; -.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
DR   TIGRFAMs; TIGR00794; kup; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q1CC44.
DR   SWISS-2DPAGE; Q1CC44.
KW   Cell inner membrane; Cell membrane; Complete proteome; Ion transport;
KW   Membrane; Potassium; Potassium transport; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    622       Low affinity potassium transport system
FT                                protein kup.
FT                                /FTId=PRO_0000279845.
FT   TOPO_DOM      1      8       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM      9     29       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM     30     45       Periplasmic. {ECO:0000255}.
FT   TRANSMEM     46     66       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM     67    100       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    101    121       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM    122    136       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    137    157       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM    158    164       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    165    185       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM    186    212       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    213    233       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM    234    246       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    247    267       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM    268    286       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    287    309       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM    310    336       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    337    357       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM    358    362       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    363    383       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM    384    394       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    395    415       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TRANSMEM    416    436       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01522}.
FT   TOPO_DOM    437    622       Cytoplasmic. {ECO:0000255}.
SQ   SEQUENCE   622 AA;  69116 MW;  8E50A38C8E89DA03 CRC64;
     MSTEHKQYLS AVTLAAIGVV YGDIGTSPLY TLRECFSGHY GFDVRPDVVF GFLSLIFWML
     ILVVSVKYLT YVMRADNAGE GGILTLMSLA GRNTSSRATS ILVVLGLIGG SFFYGEVVIT
     PAISVMSAIE GLEIAAPALD PYIVPCSIAV LTLLFVIQKH GTGSVGKLFA PVMLVWFLTL
     ALLGLRSIIA NPEVLAALNP KWAISFFVEY KSVSFFALGA VVLAITGVEA LYADMGHFGK
     FPIRLAWFTV VLPSLVLNYF GQGALLLKNP EAIKNPFFLL APDWALIPLL ILATLATVIA
     SQAVISGVFS LTRQAVRLGY LPPMRIIHTS EMESGQIYIP VINWTLYLAV VLVIIGFERS
     SNLAAAYGIA VTGTMVITSI LFCTVAWKNW HWNRFLVVFL LMVLLIIDIP MFSANVLKLF
     SGGWLPLSLG LVMFIIMTTW KSERFSLLRR MHEHSNSLEA MIASLEKSPP VRVPGTAVYM
     SRAMNVIPFA LLHNLKHNKV LHERVVLLTM RTDDVPYVHN VERVTIEQLS PTFWRVVARY
     GWRETPNVAE IFHRCGLEGL SCQMMETSFF MSHESLILTK RPWHLFLRGK LFIALSRNAL
     RAPDQFEIPP NRVIELGTQV EI
//

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