(data stored in ACNUC9543 zone)

SWISSPROT: A0A0H2Y3A7_YERPA

ID   A0A0H2Y3A7_YERPA        Unreviewed;       360 AA.
AC   A0A0H2Y3A7;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   05-DEC-2018, entry version 20.
DE   RecName: Full=Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase {ECO:0000256|HAMAP-Rule:MF_02030};
DE            EC=2.7.8.33 {ECO:0000256|HAMAP-Rule:MF_02030};
DE   AltName: Full=UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase {ECO:0000256|HAMAP-Rule:MF_02030};
DE   AltName: Full=Undecaprenyl-phosphate GlcNAc-1-phosphate transferase {ECO:0000256|HAMAP-Rule:MF_02030};
GN   Name=wecA {ECO:0000256|HAMAP-Rule:MF_02030};
GN   OrderedLocusNames=YPA_0152 {ECO:0000313|EMBL:ABG12121.1};
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102 {ECO:0000313|EMBL:ABG12121.1, ECO:0000313|Proteomes:UP000001971};
RN   [1] {ECO:0000313|EMBL:ABG12121.1, ECO:0000313|Proteomes:UP000001971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua {ECO:0000313|EMBL:ABG12121.1,
RC   ECO:0000313|Proteomes:UP000001971};
RX   PubMed=16740952; DOI=10.1128/JB.00124-06;
RA   Chain P.S., Hu P., Malfatti S.A., Radnedge L., Larimer F.,
RA   Vergez L.M., Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and
RT   Nepal516: evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- FUNCTION: Catalyzes the transfer of the GlcNAc-1-phosphate moiety
CC       from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate
CC       (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-
CC       C55). {ECO:0000256|HAMAP-Rule:MF_02030}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-
CC         alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-1-diphospho-
CC         di-trans,octa-cis-undecaprenol + UMP; Xref=Rhea:RHEA:28090,
CC         ChEBI:CHEBI:57705, ChEBI:CHEBI:57865, ChEBI:CHEBI:60392,
CC         ChEBI:CHEBI:62959; EC=2.7.8.33; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02030};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02030};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02030};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS O-antigen
CC       biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02030}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial
CC       common antigen biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02030}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02030}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02030}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 4 family. WecA
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_02030}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000308; ABG12121.1; -; Genomic_DNA.
DR   EnsemblBacteria; ABG12121; ABG12121; YPA_0152.
DR   KEGG; ypa:YPA_0152; -.
DR   KO; K02851; -.
DR   OMA; QKATMPD; -.
DR   UniPathway; UPA00281; -.
DR   UniPathway; UPA00566; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0009276; C:Gram-negative-bacterium-type cell wall; IEA:InterPro.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0008963; F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity; IEA:InterPro.
DR   GO; GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW.
DR   GO; GO:0036380; F:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009243; P:O antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02030; WecA_Gammaproteo; 1.
DR   InterPro; IPR012750; ECA_WecA-rel.
DR   InterPro; IPR000715; Glycosyl_transferase_4.
DR   PANTHER; PTHR22926; PTHR22926; 1.
DR   Pfam; PF00953; Glycos_transf_4; 1.
DR   TIGRFAMs; TIGR02380; ECA_wecA; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0H2Y3A7.
DR   SWISS-2DPAGE; A0A0H2Y3A7.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001971};
KW   Glycosyltransferase {ECO:0000256|HAMAP-Rule:MF_02030,
KW   ECO:0000313|EMBL:ABG12121.1};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Manganese {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_02030,
KW   ECO:0000313|EMBL:ABG12121.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02030}.
FT   TRANSMEM      6     28       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM     40     60       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM     66     84       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM     96    114       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    126    144       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    156    174       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    180    201       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    208    227       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    239    258       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    289    307       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    313    332       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
SQ   SEQUENCE   360 AA;  40194 MW;  0E77585C119F1300 CRC64;
     MSTELIYIFL FSMAFLFVAR KVAIKIGLVD KPNYRKRHQG LIPLVGGISV FAGVCFAFLI
     TNQQIPHFRL YLACAGLLVF VGALDDRFDI SVKIRAFVQA LVGIAMMAVA GLYLRSLGHA
     FGPWEMVLGP FGYVVTLFAV WAAINAFNMV DGIDGLLGGL SCVSFGAMGI LLYQSGQMSL
     ALWCFAMIAT IIPYILLNLG LLGRRYKVFM GDAGSTLIGF TAIWILLQAT QGNAHPINPV
     TALWIIAIPL MDMIAIMYRR LRKGMSPFSP DRQHIHHLIM RAGFTSRQAF VLITLAAALL
     AMIGVIGERL TFIPEWVMLA LFLLAFLLYG YCIKRAWRVA RFIKRFKRRM RRASKNKHES
//

If you have problems or comments...

PBIL Back to PBIL home page