(data stored in ACNUC9543 zone)

SWISSPROT: A0A0H2Y4M6_YERPA

ID   A0A0H2Y4M6_YERPA        Unreviewed;       254 AA.
AC   A0A0H2Y4M6;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   05-DEC-2018, entry version 17.
DE   RecName: Full=dTDP-fucosamine acetyltransferase {ECO:0000256|HAMAP-Rule:MF_02027};
DE            EC=2.3.1.210 {ECO:0000256|HAMAP-Rule:MF_02027};
DE   AltName: Full=TDP-fucosamine acetyltransferase {ECO:0000256|HAMAP-Rule:MF_02027};
DE   AltName: Full=dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase {ECO:0000256|HAMAP-Rule:MF_02027};
GN   Name=wecD {ECO:0000256|HAMAP-Rule:MF_02027};
GN   OrderedLocusNames=YPA_0158 {ECO:0000313|EMBL:ABG12127.1};
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102 {ECO:0000313|EMBL:ABG12127.1, ECO:0000313|Proteomes:UP000001971};
RN   [1] {ECO:0000313|EMBL:ABG12127.1, ECO:0000313|Proteomes:UP000001971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua {ECO:0000313|EMBL:ABG12127.1,
RC   ECO:0000313|Proteomes:UP000001971};
RX   PubMed=16740952; DOI=10.1128/JB.00124-06;
RA   Chain P.S., Hu P., Malfatti S.A., Radnedge L., Larimer F.,
RA   Vergez L.M., Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and
RT   Nepal516: evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- FUNCTION: Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-
CC       amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized
CC       in the biosynthesis of the enterobacterial common antigen (ECA).
CC       {ECO:0000256|HAMAP-Rule:MF_02027}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose =
CC         CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+);
CC         Xref=Rhea:RHEA:34443, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:68492, ChEBI:CHEBI:68493;
CC         EC=2.3.1.210; Evidence={ECO:0000256|HAMAP-Rule:MF_02027};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial
CC       common antigen biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02027}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_02027}.
CC   -!- SIMILARITY: Belongs to the WecD family. {ECO:0000256|HAMAP-
CC       Rule:MF_02027}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_02027}.
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DR   EMBL; CP000308; ABG12127.1; -; Genomic_DNA.
DR   EnsemblBacteria; ABG12127; ABG12127; YPA_0158.
DR   KEGG; ypa:YPA_0158; -.
DR   KO; K16704; -.
DR   OMA; TAYWFYR; -.
DR   UniPathway; UPA00566; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02027; WecD_RffC; 1.
DR   InterPro; IPR012752; AcTrfase_WecD.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   TIGRFAMs; TIGR02382; wecD_rffC; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0H2Y4M6.
DR   SWISS-2DPAGE; A0A0H2Y4M6.
KW   Acyltransferase {ECO:0000256|HAMAP-Rule:MF_02027};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001971};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_02027}.
FT   DOMAIN      106    254       N-acetyltransferase.
FT                                {ECO:0000259|PROSITE:PS51186}.
FT   ACT_SITE    237    237       Proton donor. {ECO:0000256|HAMAP-Rule:
FT                                MF_02027}.
FT   BINDING     230    230       Acetyl-CoA. {ECO:0000256|HAMAP-Rule:
FT                                MF_02027}.
SQ   SEQUENCE   254 AA;  28074 MW;  3DEACFA5B69117AE CRC64;
     MANICWIYYM PVHASIEPLG WESEFFQRQS AKLIFSDSAP PLNPAELAAF TLVQAKVPTH
     RLDLIDALSQ LDFHLVEGEI DLSLVVGEKE GIGTENATSE PNMGAYSLRV ATEADIPQLR
     RVAASAFALS RFRAPWYDAQ DSGRFYALWV EKAVLGTFDH QCLLVLDPTD QPVGFVTLRD
     LQDGSARIGL LAVFPGAQSK GIGLRLMSAA KQWCQHHGLH RLRVATQMSN IAALRLYIRS
     GASIESTAYW LCRG
//

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