(data stored in ACNUC9543 zone)

SWISSPROT: METJ_YERPA

ID   METJ_YERPA              Reviewed;         105 AA.
AC   Q1CBE1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   08-MAY-2019, entry version 80.
DE   RecName: Full=Met repressor {ECO:0000255|HAMAP-Rule:MF_00744};
DE   AltName: Full=Met regulon regulatory protein MetJ {ECO:0000255|HAMAP-Rule:MF_00744};
GN   Name=metJ {ECO:0000255|HAMAP-Rule:MF_00744};
GN   OrderedLocusNames=YPA_0262;
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua;
RX   PubMed=16740952; DOI=10.1128/JB.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F.,
RA   Vergez L.M., Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and
RT   Nepal516: evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- FUNCTION: This regulatory protein, when combined with SAM (S-
CC       adenosylmethionine) represses the expression of the methionine
CC       regulon and of enzymes involved in SAM synthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00744}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00744}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00744}.
CC   -!- DOMAIN: Does not bind DNA by a helix-turn-helix motif.
CC   -!- SIMILARITY: Belongs to the MetJ family. {ECO:0000255|HAMAP-
CC       Rule:MF_00744}.
DR   EMBL; CP000308; ABG12231.1; -; Genomic_DNA.
DR   RefSeq; WP_002208935.1; NZ_CP009906.1.
DR   SMR; Q1CBE1; -.
DR   EnsemblBacteria; ABG12231; ABG12231; YPA_0262.
DR   KEGG; ypa:YPA_0262; -.
DR   HOGENOM; HOG000271582; -.
DR   KO; K03764; -.
DR   OMA; KWNGEYI; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00490; Met_repressor_MetJ; 1.
DR   Gene3D; 1.10.140.10; -; 1.
DR   HAMAP; MF_00744; MetJ; 1.
DR   InterPro; IPR002084; Met_repressor_MetJ.
DR   InterPro; IPR023453; Met_repressor_MetJ_dom_sf.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   Pfam; PF01340; MetJ; 1.
DR   ProDom; PD020365; Met_repressor_MetJ; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q1CBE1.
DR   SWISS-2DPAGE; Q1CBE1.
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; DNA-binding;
KW   Methionine biosynthesis; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    105       Met repressor.
FT                                /FTId=PRO_1000046502.
SQ   SEQUENCE   105 AA;  12149 MW;  59984C46320582BF CRC64;
     MAEWNGEYVS PYAEHGKKSK QVKKITVSIP LKVLKILTDE RTRRQVNNLR HATNSELLCE
     AFLHAFTGQP LPNDEDLRKE RSDEIPEAAK ILMRELGVDP DTWEY
//

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