SWISSPROT: A0A0E1NMU5_YERPA

ID   A0A0E1NMU5_YERPA        Unreviewed;       294 AA.
AC   A0A0E1NMU5;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   05-DEC-2018, entry version 27.
DE   RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
DE            EC=1.5.1.20 {ECO:0000256|RuleBase:RU003862};
GN   OrderedLocusNames=YPA_0266 {ECO:0000313|EMBL:ABG12235.1};
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102 {ECO:0000313|EMBL:ABG12235.1, ECO:0000313|Proteomes:UP000001971};
RN   [1] {ECO:0000313|EMBL:ABG12235.1, ECO:0000313|Proteomes:UP000001971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua {ECO:0000313|EMBL:ABG12235.1,
RC   ECO:0000313|Proteomes:UP000001971};
RX   PubMed=16740952; DOI=10.1128/JB.00124-06;
RA   Chain P.S., Hu P., Malfatti S.A., Radnedge L., Larimer F.,
RA   Vergez L.M., Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and
RT   Nepal516: evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-
CC         5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH;
CC         Xref=Rhea:RHEA:19821, ChEBI:CHEBI:15378, ChEBI:CHEBI:15636,
CC         ChEBI:CHEBI:18608, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=1.5.1.20; Evidence={ECO:0000256|RuleBase:RU003862};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU003862};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|RuleBase:RU003862}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase
CC       family. {ECO:0000256|RuleBase:RU003862}.
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DR   EMBL; CP000308; ABG12235.1; -; Genomic_DNA.
DR   RefSeq; WP_002208933.1; NZ_CP009906.1.
DR   EnsemblBacteria; ABG12235; ABG12235; YPA_0266.
DR   EnsemblBacteria; AJJ78185; AJJ78185; CH58_3112.
DR   KEGG; ypa:YPA_0266; -.
DR   PATRIC; fig|360102.15.peg.3263; -.
DR   KO; K00297; -.
DR   OMA; FIRAETG; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR003171; Mehydrof_redctse.
DR   InterPro; IPR004620; MTHF_reductase_bac.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; SSF51730; 1.
DR   TIGRFAMs; TIGR00676; fadh2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0E1NMU5.
DR   SWISS-2DPAGE; A0A0E1NMU5.
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU004255};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001971};
KW   FAD {ECO:0000256|RuleBase:RU003862};
KW   Flavoprotein {ECO:0000256|RuleBase:RU003862};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003862,
KW   ECO:0000313|EMBL:ABG12235.1}.
SQ   SEQUENCE   294 AA;  32976 MW;  E569CA33F7C439D6 CRC64;
     MSFFHANQRE ALNQSLSELQ GQINVSFEFF PPRTSEMEDT LWSSIDRLST LKPKFVSVTY
     GANSGERDRT HSIIKGIKER TGLEAAPHLT CIDASPTQLR DIAIDYWNSG IRHIVALRGD
     LPPNSGKPEM YACDLVGLLK DVGDFDISVA AYPEIHPEAK SAQADLINLK RKIDAGANRA
     ITQFFFDVES YLRFRDRCVA TGIDVEIVPG ILPVSNFKQL QRFATMTNVR VPNWMTSIFD
     GLDNDPETRK MVGASVAMDM VKILSREGVK DFHFYTLNRA ELSYAICHTL GVRP
//