(data stored in ACNUC9543 zone)

SWISSPROT: A0A0E1NX25_YERPA

ID   A0A0E1NX25_YERPA        Unreviewed;       299 AA.
AC   A0A0E1NX25;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   08-MAY-2019, entry version 28.
DE   RecName: Full=Tyrosine recombinase XerD {ECO:0000256|HAMAP-Rule:MF_01807};
GN   Name=xerD {ECO:0000256|HAMAP-Rule:MF_01807};
GN   OrderedLocusNames=YPA_0377 {ECO:0000313|EMBL:ABG12345.1};
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102 {ECO:0000313|EMBL:ABG12345.1, ECO:0000313|Proteomes:UP000001971};
RN   [1] {ECO:0000313|EMBL:ABG12345.1, ECO:0000313|Proteomes:UP000001971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua {ECO:0000313|EMBL:ABG12345.1,
RC   ECO:0000313|Proteomes:UP000001971};
RX   PubMed=16740952; DOI=10.1128/JB.00124-06;
RA   Chain P.S., Hu P., Malfatti S.A., Radnedge L., Larimer F.,
RA   Vergez L.M., Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and
RT   Nepal516: evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by
CC       catalyzing the cutting and rejoining of the recombining DNA
CC       molecules. Binds cooperatively to specific DNA consensus sequences
CC       that are separated from XerC binding sites by a short central
CC       region, forming the heterotetrameric XerC-XerD complex that
CC       recombines DNA substrates. The complex is essential to convert
CC       dimers of the bacterial chromosome into monomers to permit their
CC       segregation at cell division. It also contributes to the
CC       segregational stability of plasmids. In the complex XerD
CC       specifically exchanges the bottom DNA strands. {ECO:0000256|HAMAP-
CC       Rule:MF_01807}.
CC   -!- ACTIVITY REGULATION: FtsK may regulate the catalytic switch
CC       between XerC and XerD in the heterotetrameric complex during the
CC       two steps of the recombination process. {ECO:0000256|HAMAP-
CC       Rule:MF_01807}.
CC   -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC       molecules of XerC and two molecules of XerD, in which XerC
CC       interacts with XerD via its C-terminal region, XerD interacts with
CC       XerC via its C-terminal region and so on. {ECO:0000256|HAMAP-
CC       Rule:MF_01807}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807,
CC       ECO:0000256|SAAS:SAAS00019473}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_01807}.
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DR   EMBL; CP000308; ABG12345.1; -; Genomic_DNA.
DR   RefSeq; WP_002209933.1; NZ_CP009906.1.
DR   SMR; A0A0E1NX25; -.
DR   EnsemblBacteria; ABG12345; ABG12345; YPA_0377.
DR   EnsemblBacteria; AJJ81475; AJJ81475; CH58_3223.
DR   KEGG; ypa:YPA_0377; -.
DR   PATRIC; fig|360102.15.peg.3385; -.
DR   KO; K04763; -.
DR   OMA; AFWYLIK; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR   HAMAP; MF_01807; Recomb_XerD; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR011932; Recomb_XerD.
DR   InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   TIGRFAMs; TIGR02225; recomb_XerD; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0E1NX25.
DR   SWISS-2DPAGE; A0A0E1NX25.
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_01807,
KW   ECO:0000256|SAAS:SAAS00608023};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_01807,
KW   ECO:0000256|SAAS:SAAS00608024};
KW   Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01807,
KW   ECO:0000256|SAAS:SAAS00608018};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001971};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01807,
KW   ECO:0000256|SAAS:SAAS00094312};
KW   DNA integration {ECO:0000256|HAMAP-Rule:MF_01807,
KW   ECO:0000256|SAAS:SAAS00298355};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01807,
KW   ECO:0000256|SAAS:SAAS00019433};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01807,
KW   ECO:0000256|SAAS:SAAS00424103}.
FT   ACT_SITE    149    149       {ECO:0000256|HAMAP-Rule:MF_01807}.
FT   ACT_SITE    173    173       {ECO:0000256|HAMAP-Rule:MF_01807}.
FT   ACT_SITE    245    245       {ECO:0000256|HAMAP-Rule:MF_01807}.
FT   ACT_SITE    248    248       {ECO:0000256|HAMAP-Rule:MF_01807}.
FT   ACT_SITE    271    271       {ECO:0000256|HAMAP-Rule:MF_01807}.
FT   ACT_SITE    280    280       O-(3'-phospho-DNA)-tyrosine intermediate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01807}.
SQ   SEQUENCE   299 AA;  34215 MW;  C9504963A42A96BA CRC64;
     MKQQDNPLIE QFLDALWLER NLAENTLASY RLDLHALVGW LTHHNSDLLR ASPQDLQSFL
     AERIEGGYKA TSSARLLSAM RRLFQYLYRE KLREDDPTAL LSSPKLPQRL PKDLSEAQVD
     ALLNSPNVDI PLELRDKAML EVLYATGLRV SELVGLTISD VSLRQGVVRV IGKGNKERLV
     PLGEEAVYWI ENYMEHGRPW LVNGASLDVL FPSNRSQQMT RQTFWHRIKH YAILAGIDSE
     RLSPHVLRHA FATHLLNHGA DLRVVQMLLG HSDLSTTQIY THVATERLRQ LHQQHHPRA
//

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