(data stored in ACNUC7421 zone)

SWISSPROT: ENTS_ECOL5

ID   ENTS_ECOL5              Reviewed;         416 AA.
AC   Q0TK80;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   11-DEC-2019, entry version 79.
DE   RecName: Full=Enterobactin exporter EntS {ECO:0000255|HAMAP-Rule:MF_01436};
GN   Name=entS {ECO:0000255|HAMAP-Rule:MF_01436}; OrderedLocusNames=ECP_0623;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=536 / UPEC;
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
CC   -!- FUNCTION: Component of an export pathway for enterobactin.
CC       {ECO:0000255|HAMAP-Rule:MF_01436}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01436}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01436}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. EntS (TC
CC       2.A.1.38) family. {ECO:0000255|HAMAP-Rule:MF_01436}.
DR   EMBL; CP000247; ABG68651.1; -; Genomic_DNA.
DR   RefSeq; WP_001041794.1; NC_008253.1.
DR   EnsemblBacteria; ABG68651; ABG68651; ECP_0623.
DR   KEGG; ecp:ECP_0623; -.
DR   eggNOG; ENOG4105E8G; Bacteria.
DR   eggNOG; COG0477; LUCA.
DR   HOGENOM; HOG000183770; -.
DR   KO; K08225; -.
DR   OMA; RNGAYGW; -.
DR   BioCyc; ECOL362663:G1G5S-652-MONOMER; -.
DR   Proteomes; UP000009182; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0042931; F:enterobactin transmembrane transporter activity; IEA:InterPro.
DR   HAMAP; MF_01436; MFS_EntS; 1.
DR   InterPro; IPR023722; Enterobactin_exp_EntS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR010290; TM_effector.
DR   Pfam; PF05977; MFS_3; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q0TK80.
DR   SWISS-2DPAGE; Q0TK80.
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..416
FT                   /note="Enterobactin exporter EntS"
FT                   /id="PRO_0000301860"
FT   TOPO_DOM        1..21
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        43..55
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        77..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        105..109
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        131..156
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        178
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        200..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        240..256
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        278..287
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        288..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        308..313
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        314..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        337..356
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        378
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
FT   TOPO_DOM        400..416
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01436"
SQ   SEQUENCE   416 AA;  43255 MW;  E6EC949770992DA5 CRC64;
     MNKQSWLLNL SLLKTHPAFR AVFLARFISI VSLGLLGVAV PVQIQMMTHS TWQVGLSVTL
     TGGAMFVGLM VGGVLADRYE RKKVILLARG TCGIGFIGLC LNALLPEPSL LAIYLLGLWD
     GFFASLGVTA LLAATPALVG RENLMQAGAI TMLTVRLGSV ISPMIGGLLL ATGGVAWNYG
     LAAAGTFITL LPLLSLPALP PPPQPREHPL KSLLAGFRFL LASPLVGGIA LLGGLLTMAS
     AVRVLYPALA DNWQMSAAQI GFLYAAIPLG AAIGALTSGK LAHSVRPGLL MLLSTLGAFL
     AIGLFGLMPM WILGVVCLAL FGWLSAVSSL LQYTMLQTQT PEAMLGRING LWTAQNVTGD
     AIGAALLGGL GAMMTPVASA SASGFGLLII GVLLLLVLVE LRRFRQTPPQ VTASGS
//

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