(data stored in ACNUC7421 zone)

SWISSPROT: Q0SKC6_RHOJR

ID   Q0SKC6_RHOJR            Unreviewed;       500 AA.
AC   Q0SKC6;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   07-JUN-2017, entry version 73.
DE   SubName: Full=Probable bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase {ECO:0000313|EMBL:ABG92010.1};
DE            EC=2.1.1.130 {ECO:0000313|EMBL:ABG92010.1};
GN   OrderedLocusNames=RHA1_ro00174 {ECO:0000313|EMBL:ABG92010.1};
OS   Rhodococcus jostii (strain RHA1).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=101510 {ECO:0000313|EMBL:ABG92010.1, ECO:0000313|Proteomes:UP000008710};
RN   [1] {ECO:0000313|Proteomes:UP000008710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1 {ECO:0000313|Proteomes:UP000008710};
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M.,
RA   Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D.,
RA   Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M.,
RA   Schein J.E., Shin H., Smailus D., Siddiqui A.S., Marra M.A.,
RA   Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M.,
RA   Davies J.E., Mohn W.W., Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000256|RuleBase:RU003960}.
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DR   EMBL; CP000431; ABG92010.1; -; Genomic_DNA.
DR   RefSeq; WP_011593487.1; NC_008268.1.
DR   ProteinModelPortal; Q0SKC6; -.
DR   STRING; 101510.RHA1_ro00174; -.
DR   PRIDE; Q0SKC6; -.
DR   EnsemblBacteria; ABG92010; ABG92010; RHA1_ro00174.
DR   GeneID; 4217593; -.
DR   KEGG; rha:RHA1_ro00174; -.
DR   PATRIC; fig|101510.16.peg.199; -.
DR   eggNOG; ENOG4105E4R; Bacteria.
DR   eggNOG; COG1010; LUCA.
DR   eggNOG; COG2243; LUCA.
DR   HOGENOM; HOG000047670; -.
DR   KO; K13540; -.
DR   OMA; SYMHMHK; -.
DR   OrthoDB; POG091H02N3; -.
DR   BioCyc; RJOS101510:GJJ1-174-MONOMER; -.
DR   Proteomes; UP000008710; Chromosome.
DR   GO; GO:0030788; F:precorrin-2 C20-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation-reduction process; IEA:InterPro.
DR   CDD; cd11645; Precorrin_2_C20_MT; 1.
DR   CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 2.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR   InterPro; IPR012382; CobI/CbiL.
DR   InterPro; IPR006364; CobI/CbiL/CobIJ_dom.
DR   InterPro; IPR003043; Uropor_MeTrfase_CS.
DR   Pfam; PF00590; TP_methylase; 2.
DR   SUPFAM; SSF53790; SSF53790; 2.
DR   TIGRFAMs; TIGR01467; cobI_cbiL; 1.
DR   TIGRFAMs; TIGR01466; cobJ_cbiH; 1.
DR   PROSITE; PS00840; SUMT_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q0SKC6.
DR   SWISS-2DPAGE; Q0SKC6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008710};
KW   Methyltransferase {ECO:0000256|RuleBase:RU003960,
KW   ECO:0000256|SAAS:SAAS00099290, ECO:0000313|EMBL:ABG92010.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008710};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00099242};
KW   Transferase {ECO:0000256|RuleBase:RU003960,
KW   ECO:0000256|SAAS:SAAS00099286, ECO:0000313|EMBL:ABG92010.1}.
FT   DOMAIN       10    221       TP_methylase. {ECO:0000259|Pfam:PF00590}.
FT   DOMAIN      257    463       TP_methylase. {ECO:0000259|Pfam:PF00590}.
SQ   SEQUENCE   500 AA;  53745 MW;  2EEF634F7B356F6B CRC64;
     MSSEERVTGK LWGVGIGPGD PELVTVKAAR VIAEADVVAF HSARHGKSIS RAVAAPYLRE
     GQIEEHLVYP VTTETVDHPG GYQGAMDEFY EEASQRLAAH LDAGRSVALL AAGDPLFYSS
     YMHMHKRLVP RFEAEVVPGV TSISAASAAL AMPLVEGEEI LTVLPGTMPP GELTRRLRET
     DAAAILKLGR TYPAVRQALK DSGRIDETWY VERASTTRQK IDAADDVSDS DVPYFSIAIV
     PSPSNARRDD AAPQGELVVV GLGPGDQAWT TPEVQHELSL ATDLVGYGPY IDRVPERPGQ
     RRHSSDNRVE AERAAMALDL AKNGSRVAVV SSGDPGVFAM AAAVLEVAAE EQWRGVPVRV
     LPGMTAANAV ASRVGAPLGH DYAVLSLSDR LKPWDVVAQR ISAVASADMA FAVYNPASKS
     RTWQVAAMRD LVLEHRSPDT PVIIGRDVAG AQESVRVVRL ADLDPAEIDM RCLLIVGSSM
     TTVVENEHGT RVFTPRRYPG
//

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