(data stored in SCRATCH3701 zone)

SWISSPROT: DER_SYNS3

ID   DER_SYNS3               Reviewed;         455 AA.
AC   Q0ICK8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   11-DEC-2019, entry version 91.
DE   RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE   AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN   Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN   OrderedLocusNames=sync_0596;
OS   Synechococcus sp. (strain CC9311).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=64471;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9311;
RX   PubMed=16938853; DOI=10.1073/pnas.0602963103;
RA   Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H.,
RA   Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S.,
RA   Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R.,
RA   Paulsen I.T.;
RT   "Genome sequence of Synechococcus CC9311: insights into adaptation to a
RT   coastal environment.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006).
CC   -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC       ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC   -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_00195}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00195}.
DR   EMBL; CP000435; ABI46603.1; -; Genomic_DNA.
DR   RefSeq; WP_011618541.1; NC_008319.1.
DR   SMR; Q0ICK8; -.
DR   STRING; 64471.sync_0596; -.
DR   PRIDE; Q0ICK8; -.
DR   EnsemblBacteria; ABI46603; ABI46603; sync_0596.
DR   KEGG; syg:sync_0596; -.
DR   eggNOG; ENOG4105DKZ; Bacteria.
DR   eggNOG; COG1160; LUCA.
DR   HOGENOM; HOG000242861; -.
DR   KO; K03977; -.
DR   OMA; FCNLPQY; -.
DR   OrthoDB; 263682at2; -.
DR   BioCyc; SSP64471:G1G72-578-MONOMER; -.
DR   Proteomes; UP000001961; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.20; -; 1.
DR   HAMAP; MF_00195; GTPase_Der; 1.
DR   InterPro; IPR031166; G_ENGA.
DR   InterPro; IPR016484; GTP-bd_EngA.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR032859; KH_dom-like.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   Pfam; PF14714; KH_dom-like; 1.
DR   Pfam; PF01926; MMR_HSR1; 2.
DR   PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 2.
DR   PROSITE; PS51712; G_ENGA; 2.
PE   3: Inferred from homology;
DR   PRODOM; Q0ICK8.
DR   SWISS-2DPAGE; Q0ICK8.
KW   GTP-binding; Nucleotide-binding; Reference proteome; Repeat;
KW   Ribosome biogenesis.
FT   CHAIN           1..455
FT                   /note="GTPase Der"
FT                   /id="PRO_1000011771"
FT   DOMAIN          4..169
FT                   /note="EngA-type G 1"
FT   DOMAIN          178..353
FT                   /note="EngA-type G 2"
FT   DOMAIN          354..439
FT                   /note="KH-like"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   NP_BIND         10..17
FT                   /note="GTP 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   NP_BIND         57..61
FT                   /note="GTP 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   NP_BIND         120..123
FT                   /note="GTP 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   NP_BIND         184..191
FT                   /note="GTP 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   NP_BIND         231..235
FT                   /note="GTP 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT   NP_BIND         296..299
FT                   /note="GTP 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
SQ   SEQUENCE   455 AA;  51082 MW;  555B6E97403BC5C4 CRC64;
     MARPVVAIIG RPNVGKSTLV NRLCRSREAI VHDQPGVTRD RTYQDGYWGD REFKVVDTGG
     LVFDDDSEFL PEIREQASLA LAEASVALVI VDGQQGLTAA DESIAEWLRT QNCKTLLAVN
     KCESPEQGLG MAAEFWRLGL GEPHPISAIH GAGTAELLDQ VLTFLPPKDE ESDEEEPIQL
     SIIGRPNVGK SSLLNSICGE TRAIVSPIRG TTRDTIDTRI ERENRRWRLI DTAGIRRRRS
     VNYGPEFFGI NRSFKAIERS DVCVLVIDAL DGVTEQDQRL AGRIEEDGRA CVVVVNKWDA
     VEKDSHTMTA MEKELRAKLY FLDWAPMLFT SALTGQRVDS IFALAALAVE QHRRRVSTSV
     VNEVLKEALS WRSPPTTRGG RQGRLYYGTQ VASRPPSFTL FVNEPKLFGD TYRRYVERQI
     REGLGFDGTP VKLFWRGKQQ RDAEKELVRQ QNRQG
//

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