(data stored in SCRATCH3701 zone)

SWISSPROT: SYH_SYNS3

ID   SYH_SYNS3               Reviewed;         428 AA.
AC   Q0IDK4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   11-DEC-2019, entry version 87.
DE   RecName: Full=Histidine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00127};
DE            EC=6.1.1.21 {ECO:0000255|HAMAP-Rule:MF_00127};
DE   AltName: Full=Histidyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00127};
DE            Short=HisRS {ECO:0000255|HAMAP-Rule:MF_00127};
GN   Name=hisS {ECO:0000255|HAMAP-Rule:MF_00127}; OrderedLocusNames=sync_0232;
OS   Synechococcus sp. (strain CC9311).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=64471;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9311;
RX   PubMed=16938853; DOI=10.1073/pnas.0602963103;
RA   Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H.,
RA   Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S.,
RA   Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R.,
RA   Paulsen I.T.;
RT   "Genome sequence of Synechococcus CC9311: insights into adaptation to a
RT   coastal environment.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC         histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC         Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00127};
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00127}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00127}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00127}.
DR   EMBL; CP000435; ABI47698.1; -; Genomic_DNA.
DR   RefSeq; WP_011618216.1; NC_008319.1.
DR   SMR; Q0IDK4; -.
DR   STRING; 64471.sync_0232; -.
DR   EnsemblBacteria; ABI47698; ABI47698; sync_0232.
DR   KEGG; syg:sync_0232; -.
DR   eggNOG; ENOG4105CUT; Bacteria.
DR   eggNOG; COG0124; LUCA.
DR   HOGENOM; HOG000018072; -.
DR   KO; K01892; -.
DR   OMA; CDFDFIG; -.
DR   OrthoDB; 277998at2; -.
DR   BioCyc; SSP64471:G1G72-226-MONOMER; -.
DR   Proteomes; UP000001961; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd00773; HisRS-like_core; 1.
DR   CDD; cd00859; HisRS_anticodon; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   HAMAP; MF_00127; His_tRNA_synth; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR015807; His-tRNA-ligase.
DR   InterPro; IPR041715; HisRS-like_core.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   InterPro; IPR033656; HisRS_anticodon.
DR   PANTHER; PTHR43707; PTHR43707; 1.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF13393; tRNA-synt_His; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   TIGRFAMs; TIGR00442; hisS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q0IDK4.
DR   SWISS-2DPAGE; Q0IDK4.
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..428
FT                   /note="Histidine--tRNA ligase"
FT                   /id="PRO_1000016474"
SQ   SEQUENCE   428 AA;  47155 MW;  19758B6C545C15D5 CRC64;
     MSQLQTLRGM VDLLPEQTRR WQAVESVARE HFRCAGLDEI RTPLLEFTDL FARGIGEGTD
     VVGKEMYTFL DRGDRSCTLR PEGTASVVRA ALQHGLLSQG AQRLWYGGPM FRYERPQAGR
     QRQFHQIGVE FLGASSPRSD AEVIALAWDL LTDLGIQGLN LEINSLGTPD DRQRFRSELV
     QWLEERVEQL DAESQARLTT NPLRILDSKD KGTQQLLNDA PTLLKALSKE SVDRFEQVCA
     LLTALQIPYQ LNPRLVRGLD YYGHTAFEIT SDQLGAQATV CGGGRYDGLI QQLGGPVTPA
     IGWALGMERL LLVISAAAQA DPDGAAARLT ATPSPLVYVI NRGEQAEPQA LSLARQWRGA
     GLAVELDGSS ASFGKQFKRA DRSGAPWAVV LGDEEASAGQ VRLKPLRGEG EEKQLTWEDA
     LSYLMKQR
//

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