(data stored in ACNUC7421 zone)

SWISSPROT: DNAA_PSEAB

ID   DNAA_PSEAB              Reviewed;         514 AA.
AC   Q02V80;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   07-JUN-2017, entry version 72.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=PA14_00010;
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000438; ABJ14957.1; -; Genomic_DNA.
DR   RefSeq; WP_003109151.1; NC_008463.1.
DR   ProteinModelPortal; Q02V80; -.
DR   SMR; Q02V80; -.
DR   EnsemblBacteria; ABJ14957; ABJ14957; PA14_00010.
DR   KEGG; pau:PA14_00010; -.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q02V80.
DR   SWISS-2DPAGE; Q02V80.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA replication;
KW   DNA-binding; Nucleotide-binding.
FT   CHAIN         1    514       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000048692.
FT   NP_BIND     219    226       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   514 AA;  57754 MW;  ACEE3916221E2E84 CRC64;
     MSVELWQQCV DLLRDELPSQ QFNTWIRPLQ VEAEGDELRV YAPNRFVLDW VNEKYLGRLL
     ELLGERGEGQ LPALSLLIGS KRSRTPRAAI VPSQTHVAPP PPVAPPPAPV QPVSAAPVVV
     PREELPPVTT APSVSSDPYE PEEPSIDPLA AAMPAGAAPA VRTERNVQVE GALKHTSYLN
     RTFTFENFVE GKSNQLARAA AWQVADNLKH GYNPLFLYGG VGLGKTHLMH AVGNHLLKKN
     PNAKVVYLHS ERFVADMVKA LQLNAINEFK RFYRSVDALL IDDIQFFARK ERSQEEFFHT
     FNALLEGGQQ VILTSDRYPK EIEGLEERLK SRFGWGLTVA VEPPELETRV AILMKKAEQA
     KIELPHDAAF FIAQRIRSNV RELEGALKRV IAHSHFMGRP ITIELIRESL KDLLALQDKL
     VSIDNIQRTV AEYYKIKISD LLSKRRSRSV ARPRQVAMAL SKELTNHSLP EIGVAFGGRD
     HTTVLHACRK IAQLRESDAD IREDYKNLLR TLTT
//

If you have problems or comments...

PBIL Back to PBIL home page