(data stored in ACNUC7421 zone)

SWISSPROT: A0A0H2ZK46_PSEAB

ID   A0A0H2ZK46_PSEAB        Unreviewed;       530 AA.
AC   A0A0H2ZK46;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   05-JUL-2017, entry version 17.
DE   RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|RuleBase:RU363061};
DE            EC=1.9.3.1 {ECO:0000256|RuleBase:RU363061};
GN   Name=coxA {ECO:0000313|EMBL:ABJ15063.1};
GN   OrderedLocusNames=PA14_01300 {ECO:0000313|EMBL:ABJ15063.1};
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963 {ECO:0000313|EMBL:ABJ15063.1, ECO:0000313|Proteomes:UP000000653};
RN   [1] {ECO:0000313|EMBL:ABJ15063.1, ECO:0000313|Proteomes:UP000000653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14 {ECO:0000313|EMBL:ABJ15063.1,
RC   ECO:0000313|Proteomes:UP000000653};
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. CO I is the
CC       catalytic subunit of the enzyme. Electrons originating in
CC       cytochrome c are transferred via the copper A center of subunit 2
CC       and heme A of subunit 1 to the bimetallic center formed by heme A3
CC       and copper B. {ECO:0000256|RuleBase:RU363061}.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O. {ECO:0000256|RuleBase:RU363061}.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC       {ECO:0000256|RuleBase:RU363061}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU363061}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363061}.
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
CC       {ECO:0000256|RuleBase:RU363061}.
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DR   EMBL; CP000438; ABJ15063.1; -; Genomic_DNA.
DR   RefSeq; WP_003083723.1; NC_008463.1.
DR   ProteinModelPortal; A0A0H2ZK46; -.
DR   EnsemblBacteria; ABJ15063; ABJ15063; PA14_01300.
DR   KEGG; pau:PA14_01300; -.
DR   KO; K02274; -.
DR   OMA; SFAMVIR; -.
DR   UniPathway; UPA00705; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045277; C:respiratory chain complex IV; IEA:InterPro.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd01663; Cyt_c_Oxidase_I; 1.
DR   Gene3D; 1.20.210.10; -; 1.
DR   InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
DR   InterPro; IPR000883; Cyt_C_Oxase_1.
DR   InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR   InterPro; IPR033944; Cyt_c_oxase_su1_dom.
DR   InterPro; IPR014241; Cyt_c_oxidase_su1_bac.
DR   PANTHER; PTHR10422; PTHR10422; 1.
DR   Pfam; PF00115; COX1; 1.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   SUPFAM; SSF81442; SSF81442; 1.
DR   TIGRFAMs; TIGR02891; CtaD_CoxA; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS00077; COX1_CUB; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0H2ZK46.
DR   SWISS-2DPAGE; A0A0H2ZK46.
KW   Cell membrane {ECO:0000256|RuleBase:RU363061};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000653};
KW   Copper {ECO:0000256|RuleBase:RU363061};
KW   Electron transport {ECO:0000256|RuleBase:RU363061};
KW   Heme {ECO:0000256|RuleBase:RU363061};
KW   Iron {ECO:0000256|RuleBase:RU363061};
KW   Membrane {ECO:0000256|RuleBase:RU363061};
KW   Metal-binding {ECO:0000256|RuleBase:RU363061};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU363061};
KW   Respiratory chain {ECO:0000256|RuleBase:RU363061};
KW   Transmembrane {ECO:0000256|RuleBase:RU363061};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363061};
KW   Transport {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM     38     59       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM     79    100       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    121    141       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    161    189       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    201    229       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    261    280       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    292    314       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    320    342       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    354    378       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    390    414       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    435    453       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    473    493       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   DOMAIN       26    530       COX1. {ECO:0000259|PROSITE:PS50855}.
SQ   SEQUENCE   530 AA;  58794 MW;  769EB7B1472CF942 CRC64;
     MSAVIDTPDH HAGDHHHGPA KGLMRWVLTT NHKDIGTLYL WFSFMMFLLG GSMAMVIRAE
     LFQPGLQIVE PAFFNQMTTM HGLIMVFGAV MPAFVGLANW MIPLMIGAPD MALPRMNNFS
     FWLLPAAFGL LVSTLFMPGG GPNFGWTFYA PLSTTFAPHS VTFFIFAIHL AGISSIMGAI
     NVIATILNLR APGMTLMKMP LFVWTWLITA FLLIAVMPVL AGVVTMMLMD IHFGTSFFSA
     AGGGDPVLFQ HVFWFFGHPE VYIMILPAFG AVSAIIPTFA RKPLFGYTSM VYATASIAFL
     SFVVWAHHMF VVGIPVTGEL FFMYATMLIA VPTGVKVFNW VTTMWEGSLT FETPMLFAVA
     FVILFTIGGF SGLMLAIAPA DFQYHDTYFV VAHFHYVLVP GAIFGIFASA YYWLPKWTGH
     MYDETLGKLH FWMSFIGMNL AFFPMHFVGL AGMPRRIPDY NLQFADFNMV SSIGAFMFGT
     TQLLFLFIVI KCIRGGKPAP AKPWDGAEGL EWSIPSPAPY HTFSTPPEVK
//

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