(data stored in ACNUC7421 zone)

SWISSPROT: CYOE1_PSEAB

ID   CYOE1_PSEAB             Reviewed;         304 AA.
AC   Q02UW5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   07-JUN-2017, entry version 66.
DE   RecName: Full=Protoheme IX farnesyltransferase 1 {ECO:0000255|HAMAP-Rule:MF_00154};
DE            EC=2.5.1.- {ECO:0000255|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme B farnesyltransferase 1 {ECO:0000255|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme O synthase 1 {ECO:0000255|HAMAP-Rule:MF_00154};
GN   Name=cyoE1 {ECO:0000255|HAMAP-Rule:MF_00154};
GN   OrderedLocusNames=PA14_01380;
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC       biosynthesis; heme O from protoheme: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00154}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       Protoheme IX farnesyltransferase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
DR   EMBL; CP000438; ABJ15070.1; -; Genomic_DNA.
DR   RefSeq; WP_003083746.1; NC_008463.1.
DR   ProteinModelPortal; Q02UW5; -.
DR   EnsemblBacteria; ABJ15070; ABJ15070; PA14_01380.
DR   KEGG; pau:PA14_01380; -.
DR   HOGENOM; HOG000237291; -.
DR   KO; K02301; -.
DR   OMA; HRKEEYA; -.
DR   UniPathway; UPA00834; UER00712.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:InterPro.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd13957; PT_UbiA_Cox10; 1.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q02UW5.
DR   SWISS-2DPAGE; Q02UW5.
KW   Cell inner membrane; Cell membrane; Complete proteome;
KW   Heme biosynthesis; Membrane; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    304       Protoheme IX farnesyltransferase 1.
FT                                /FTId=PRO_0000326919.
FT   TRANSMEM     24     44       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM     47     67       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM     99    119       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    122    142       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    150    170       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    176    196       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    228    248       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    280    300       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
SQ   SEQUENCE   304 AA;  33430 MW;  DC278071764B671C CRC64;
     MATVIDRHSQ PTWRDFLELT KPKVVVLMLI TSLIGMLLAT KAPLDGFVPW QVLIFGNLGI
     GLCAGAAAAV NHVVDRRIDS IMARTHKRPL AEGRVSPSMA LGFALLLALA GMAVLLAFTN
     PLTAWLTLAS LLGYAALYTG FLKRATPQNI VIGGLAGAAP PLLGWVAITG HLSAEPLLLV
     LIIFAWTPPH FWALCIHRKD EYAKADIPML PVTHGERYTK LHILLYTLVL FAVSLMPFVI
     HMSGLVYLLC ALALGARFLD WAWALYCDSR PHAAIKTFKY SIVYLFLLFM ALLVDHYLPL
     KLLL
//

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