(data stored in ACNUC7421 zone)

SWISSPROT: ADE_PSEAB

ID   ADE_PSEAB               Reviewed;         316 AA.
AC   Q02UT0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   05-JUL-2017, entry version 68.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01962};
DE            Short=ADE {ECO:0000255|HAMAP-Rule:MF_01962};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01962};
DE   AltName: Full=Adenine aminohydrolase {ECO:0000255|HAMAP-Rule:MF_01962};
DE            Short=AAH {ECO:0000255|HAMAP-Rule:MF_01962};
GN   OrderedLocusNames=PA14_01830;
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: Catalyzes the hydrolytic deamination of adenine to
CC       hypoxanthine. Plays an important role in the purine salvage
CC       pathway and in nitrogen catabolism. {ECO:0000255|HAMAP-
CC       Rule:MF_01962}.
CC   -!- CATALYTIC ACTIVITY: Adenine + H(2)O = hypoxanthine + NH(3).
CC       {ECO:0000255|HAMAP-Rule:MF_01962}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01962};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01962};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases
CC       superfamily. Adenosine and AMP deaminases family. Adenine
CC       deaminase type 2 subfamily. {ECO:0000255|HAMAP-Rule:MF_01962}.
DR   EMBL; CP000438; ABJ15105.1; -; Genomic_DNA.
DR   RefSeq; WP_003083850.1; NC_008463.1.
DR   ProteinModelPortal; Q02UT0; -.
DR   SMR; Q02UT0; -.
DR   EnsemblBacteria; ABJ15105; ABJ15105; PA14_01830.
DR   KEGG; pau:PA14_01830; -.
DR   HOGENOM; HOG000218813; -.
DR   KO; K21053; -.
DR   OMA; DERLMQR; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd01320; ADA; 1.
DR   HAMAP; MF_01962; Adenine_deaminase; 1.
DR   InterPro; IPR001365; A/AMP_deaminase_dom.
DR   InterPro; IPR028892; ADE.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01430; aden_deam; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q02UT0.
DR   SWISS-2DPAGE; Q02UT0.
KW   Complete proteome; Hydrolase; Metal-binding; Nucleotide metabolism;
KW   Zinc.
FT   CHAIN         1    316       Adenine deaminase.
FT                                /FTId=PRO_1000017678.
FT   ACT_SITE    197    197       Proton donor. {ECO:0000255|HAMAP-
FT                                Rule:MF_01962}.
FT   METAL        14     14       Zinc; catalytic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01962}.
FT   METAL        16     16       Zinc; catalytic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01962}.
FT   METAL       194    194       Zinc; catalytic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01962}.
FT   METAL       275    275       Zinc; catalytic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01962}.
FT   BINDING     276    276       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_01962}.
FT   SITE        218    218       Important for catalytic activity.
FT                                {ECO:0000255|HAMAP-Rule:MF_01962}.
SQ   SEQUENCE   316 AA;  36135 MW;  FEEB18CED62CF184 CRC64;
     MYEWLNALPK AELHLHLEGT LEPELLFALA ERNRIALPWN DVETLRKAYA FNNLQEFLDL
     YYAGADVLRT EQDFYDLTWA YLQKCKAQNV VHVEPFFDPQ THTDRGIPFE VVLAGIRAAL
     QDGEKLLGIR HGLILSFLRH LSEEQAQKTL DQALPFRDAF IAVGLDSSEV GHPPSKFQRV
     FDRARSEGFL TVAHAGEEGP PEYIWEALDL LKVERIDHGV RAFEDERLMR RLIDEQIPLT
     VCPLSNTKLC VFDDMSQHTI LDMLERGVKV TVNSDDPAYF GGYVTENFHA LQQSLGMTEE
     QARRLAQNSL DARLVK
//

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