(data stored in ACNUC7421 zone)

SWISSPROT: A0A0H2ZKT5_PSEAB

ID   A0A0H2ZKT5_PSEAB        Unreviewed;       451 AA.
AC   A0A0H2ZKT5;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   07-JUN-2017, entry version 11.
DE   RecName: Full=Signal recognition particle receptor FtsY {ECO:0000256|HAMAP-Rule:MF_00920};
DE            Short=SRP receptor {ECO:0000256|HAMAP-Rule:MF_00920};
GN   Name=ftsY {ECO:0000256|HAMAP-Rule:MF_00920,
GN   ECO:0000313|EMBL:ABJ15339.1};
GN   OrderedLocusNames=PA14_04900 {ECO:0000313|EMBL:ABJ15339.1};
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963 {ECO:0000313|EMBL:ABJ15339.1, ECO:0000313|Proteomes:UP000000653};
RN   [1] {ECO:0000313|EMBL:ABJ15339.1, ECO:0000313|Proteomes:UP000000653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14 {ECO:0000313|EMBL:ABJ15339.1,
RC   ECO:0000313|Proteomes:UP000000653};
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC       proteins into the cytoplasmic membrane. Acts as a receptor for the
CC       complex formed by the signal recognition particle (SRP) and the
CC       ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to
CC       the transfer of the RNC complex to the Sec translocase for
CC       insertion into the membrane, the hydrolysis of GTP by both Ffh and
CC       FtsY, and the dissociation of the SRP-FtsY complex into the
CC       individual components. {ECO:0000256|HAMAP-Rule:MF_00920}.
CC   -!- SUBUNIT: Part of the signal recognition particle protein
CC       translocation system, which is composed of SRP and FtsY. SRP is a
CC       ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.
CC       {ECO:0000256|HAMAP-Rule:MF_00920}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_00920}; Peripheral membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_00920}; Cytoplasmic side {ECO:0000256|HAMAP-
CC       Rule:MF_00920}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00920}.
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. FtsY subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00920}.
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DR   EMBL; CP000438; ABJ15339.1; -; Genomic_DNA.
DR   RefSeq; WP_004365026.1; NC_008463.1.
DR   EnsemblBacteria; ABJ15339; ABJ15339; PA14_04900.
DR   KEGG; pau:PA14_04900; -.
DR   KO; K03110; -.
DR   OMA; GISDQFQ; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031226; C:intrinsic component of plasma membrane; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   HAMAP; MF_00920; FtsY; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR   InterPro; IPR004390; SR_rcpt_FtsY.
DR   InterPro; IPR000897; SRP54_GTPase_dom.
DR   PANTHER; PTHR43134:SF1; PTHR43134:SF1; 1.
DR   Pfam; PF00448; SRP54; 1.
DR   Pfam; PF02881; SRP54_N; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00962; SRP54; 1.
DR   SMART; SM00963; SRP54_N; 1.
DR   SUPFAM; SSF47364; SSF47364; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00064; ftsY; 1.
DR   PROSITE; PS00300; SRP54; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0H2ZKT5.
DR   SWISS-2DPAGE; A0A0H2ZKT5.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000653};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00920};
KW   GTP-binding {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Receptor {ECO:0000256|HAMAP-Rule:MF_00920,
KW   ECO:0000313|EMBL:ABJ15339.1}.
FT   DOMAIN      419    432       SRP54. {ECO:0000259|PROSITE:PS00300}.
FT   NP_BIND     252    259       GTP. {ECO:0000256|HAMAP-Rule:MF_00920}.
FT   NP_BIND     334    338       GTP. {ECO:0000256|HAMAP-Rule:MF_00920}.
FT   NP_BIND     398    401       GTP. {ECO:0000256|HAMAP-Rule:MF_00920}.
SQ   SEQUENCE   451 AA;  47939 MW;  C7AA26837FFA992D CRC64;
     MFGSNDDKKA PQGGEKKGLF GWWRKKPQAG EQPADQPVEP VSETAAAEQR APADDVAQSL
     TEQPGRQQPS AAEPAEPPAP VAEAPLAGDE PASAEEHSPR PEAPVAQPEP ILAAEPEPEP
     EPEPEPVAPL AAAPAVSEPA TRPGFFARLR QGLSKTSASI GEGMASLFLG RKEIDDDLLD
     DIETRLLTAD VGVEATTLIV QNLTKRVARK ELADSGALYK ALQEELASLL RPVEQPLQVD
     VAREPYVILV VGVNGVGKTT TIGKLAKKLQ LEGKKVMLAA GDTFRAAAVE QLQVWGERNR
     IPVIAQHTGA DSASVIFDAV QAAKARGIDV LIADTAGRLH TKDNLMEELK KVRRVIGKLD
     ETAPHEVLLV LDAGTGQNAI NQAKQFNLAV ELTGLALTKL DGTAKGGVIF ALAKQFGLPI
     RYIGVGEGID DLRTFEADAF VQALFAEREN A
//

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