(data stored in ACNUC7421 zone)

SWISSPROT: A0A0H2ZK67_PSEAB

ID   A0A0H2ZK67_PSEAB        Unreviewed;       639 AA.
AC   A0A0H2ZK67;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   05-DEC-2018, entry version 19.
DE   RecName: Full=ATP-dependent RNA helicase RhlE {ECO:0000256|HAMAP-Rule:MF_00968};
DE            EC=3.6.4.13 {ECO:0000256|HAMAP-Rule:MF_00968};
GN   Name=rhlE {ECO:0000256|HAMAP-Rule:MF_00968,
GN   ECO:0000313|EMBL:ABJ15395.1};
GN   OrderedLocusNames=PA14_05560 {ECO:0000313|EMBL:ABJ15395.1};
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963 {ECO:0000313|EMBL:ABJ15395.1, ECO:0000313|Proteomes:UP000000653};
RN   [1] {ECO:0000313|EMBL:ABJ15395.1, ECO:0000313|Proteomes:UP000000653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14 {ECO:0000313|EMBL:ABJ15395.1,
RC   ECO:0000313|Proteomes:UP000000653};
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: DEAD-box RNA helicase involved in ribosome assembly. Has
CC       RNA-dependent ATPase activity and unwinds double-stranded RNA.
CC       {ECO:0000256|HAMAP-Rule:MF_00968}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00968};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00968}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. RhlE
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_00968}.
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DR   EMBL; CP000438; ABJ15395.1; -; Genomic_DNA.
DR   RefSeq; WP_003084635.1; NC_008463.1.
DR   EnsemblBacteria; ABJ15395; ABJ15395; PA14_05560.
DR   KEGG; pau:PA14_05560; -.
DR   KO; K11927; -.
DR   OMA; KAKNRSI; -.
DR   BioCyc; PAER208963:G1G74-464-MONOMER; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004004; F:ATP-dependent RNA helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0042255; P:ribosome assembly; IEA:InterPro.
DR   CDD; cd00079; HELICc; 1.
DR   HAMAP; MF_00968; DEAD_helicase_RhlE; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR028622; DEAD_helicase_RhlE.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0H2ZK67.
DR   SWISS-2DPAGE; A0A0H2ZK67.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00968,
KW   ECO:0000256|RuleBase:RU000492};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000653};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00968};
KW   Helicase {ECO:0000256|HAMAP-Rule:MF_00968,
KW   ECO:0000256|RuleBase:RU000492, ECO:0000313|EMBL:ABJ15395.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00968,
KW   ECO:0000256|RuleBase:RU000492};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00968,
KW   ECO:0000256|RuleBase:RU000492};
KW   Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_00968}.
FT   DOMAIN        1     29       Q_MOTIF. {ECO:0000259|PROSITE:PS51195}.
FT   DOMAIN       32    212       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      238    383       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   MOTIF         1     29       Q motif. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00552}.
SQ   SEQUENCE   639 AA;  70142 MW;  9B678264A84F811D CRC64;
     MSFSSLGLSE ALARAVEAAG YSQPTPVQQR AIPAVLQGRD LMVAAQTGTG KTGGFALPVL
     ERLFPAGHPD REHRHGPRQA RVLVLTPTRE LAAQVHDSFK VYARDLPLNS TCIFGGVGMN
     PQIQALAKGV DVLVACPGRL LDLAGQNKVD LSHVEILVLD EADRMLDMGF IHDVKKVLAK
     LPPKRQNLLF SATFSKDIVD LANKLLHNPE RIEVTPPNTT VERIEQRVFR LPAPQKRALL
     AHLVTVGAWE QVLVFTRTKH GANRLAEYLT KHGLPAAAIH GNKSQNARTK ALADFKANDV
     RILVATDIAA RGLDIDQLPH VVNYELPNVE EDYVHRIGRT GRAGRSGEAI SLVAPDEEKL
     LKAIEKMTRQ RIPDGDAQGF DPEAVLPEVA QPEPREAPQK QPRRDKERRS SRERKPKDAQ
     ASNPDSNVAA AQDGTEKPAG KRRRRGGKNK ENREAGQAQQ PRQSREARPA KPNRPPEVDG
     NRDPEEFLDD DFDNFGNRAD YVSPYQGQEN KGRGRRGGQQ KPQGGTGQQG RGQGQGQARG
     KSQGAAQGGA RGQGAGQGKA KKPRASKPRG QGRENASRMS DAPLREPSEY GTGKQPSRQP
     VVINKRDLVR MDRFPTAEQL DELEPRRKGE RPALLTRNR
//

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