(data stored in ACNUC7421 zone)

SWISSPROT: A0A0H2ZLC0_PSEAB

ID   A0A0H2ZLC0_PSEAB        Unreviewed;       274 AA.
AC   A0A0H2ZLC0;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   07-JUN-2017, entry version 12.
DE   RecName: Full=Malonyl-[acyl-carrier protein] O-methyltransferase {ECO:0000256|HAMAP-Rule:MF_00835, ECO:0000256|SAAS:SAAS00643773};
DE            Short=Malonyl-ACP O-methyltransferase {ECO:0000256|HAMAP-Rule:MF_00835};
DE            EC=2.1.1.197 {ECO:0000256|HAMAP-Rule:MF_00835, ECO:0000256|SAAS:SAAS00643773};
DE   AltName: Full=Biotin synthesis protein BioC {ECO:0000256|HAMAP-Rule:MF_00835};
GN   Name=bioC {ECO:0000256|HAMAP-Rule:MF_00835,
GN   ECO:0000313|EMBL:ABJ15465.1};
GN   OrderedLocusNames=PA14_06540 {ECO:0000313|EMBL:ABJ15465.1};
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963 {ECO:0000313|EMBL:ABJ15465.1, ECO:0000313|Proteomes:UP000000653};
RN   [1] {ECO:0000313|EMBL:ABJ15465.1, ECO:0000313|Proteomes:UP000000653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14 {ECO:0000313|EMBL:ABJ15465.1,
RC   ECO:0000313|Proteomes:UP000000653};
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: Converts the free carboxyl group of a malonyl-thioester
CC       to its methyl ester by transfer of a methyl group from S-adenosyl-
CC       L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the
CC       fatty acid synthetic pathway. {ECO:0000256|HAMAP-Rule:MF_00835,
CC       ECO:0000256|SAAS:SAAS00643778}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + malonyl-[acyl-
CC       carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-
CC       carrier protein] methyl ester. {ECO:0000256|HAMAP-Rule:MF_00835,
CC       ECO:0000256|SAAS:SAAS00643771}.
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00835, ECO:0000256|SAAS:SAAS00643772}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00835, ECO:0000256|SAAS:SAAS00643774}.
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DR   EMBL; CP000438; ABJ15465.1; -; Genomic_DNA.
DR   RefSeq; WP_003084830.1; NC_008463.1.
DR   ProteinModelPortal; A0A0H2ZLC0; -.
DR   EnsemblBacteria; ABJ15465; ABJ15465; PA14_06540.
DR   KEGG; pau:PA14_06540; -.
DR   KO; K02169; -.
DR   OMA; ATYQVVY; -.
DR   UniPathway; UPA00078; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0010340; F:carboxyl-O-methyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00835; BioC; 1.
DR   InterPro; IPR011814; BioC.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR02072; BioC; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0H2ZLC0.
DR   SWISS-2DPAGE; A0A0H2ZLC0.
KW   Biotin biosynthesis {ECO:0000256|HAMAP-Rule:MF_00835,
KW   ECO:0000256|SAAS:SAAS00643775};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000653};
KW   Methyltransferase {ECO:0000256|HAMAP-Rule:MF_00835,
KW   ECO:0000256|SAAS:SAAS00643776};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_00835,
KW   ECO:0000256|SAAS:SAAS00643777};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00835,
KW   ECO:0000256|SAAS:SAAS00643770}.
FT   DOMAIN       62    155       Methyltransf_11. {ECO:0000259|Pfam:
FT                                PF08241}.
SQ   SEQUENCE   274 AA;  29684 MW;  0FE6E99B29DD4F45 CRC64;
     MPDDSAPLLA PHGVAALPDK RRVAASFSRA AASYDAVAEL QRGVGESLLS ALPEGFSPRR
     WVDLGCGTGH FSRALERRFG AAEGLAVDIA EGMLRHARAR GGASHFIGGD AERLPLRDGS
     CDLLFSSLAI QWCADLPAVL AEARRVLRPG GVLAFSSLCV GTLGELRDSW RVVDGFVHVN
     RFRAFADYLQ HAAGSGLLPL TLRHEDRVLH FPDLRSLTHE LKALGAHNLN PGRPDGLTGR
     QRIRALVAAY ERFRQPEGLP ATYRVVFGVL RKDS
//

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