(data stored in ACNUC7421 zone)

SWISSPROT: A0A0H2ZL79_PSEAB

ID   A0A0H2ZL79_PSEAB        Unreviewed;       353 AA.
AC   A0A0H2ZL79;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   07-JUN-2017, entry version 16.
DE   RecName: Full=D-erythrose-4-phosphate dehydrogenase {ECO:0000256|SAAS:SAAS00673683};
DE            EC=1.2.1.72 {ECO:0000256|SAAS:SAAS00673675};
GN   Name=epd {ECO:0000313|EMBL:ABJ15514.1};
GN   OrderedLocusNames=PA14_07170 {ECO:0000313|EMBL:ABJ15514.1};
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963 {ECO:0000313|EMBL:ABJ15514.1, ECO:0000313|Proteomes:UP000000653};
RN   [1] {ECO:0000313|EMBL:ABJ15514.1, ECO:0000313|Proteomes:UP000000653}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14 {ECO:0000313|EMBL:ABJ15514.1,
RC   ECO:0000313|Proteomes:UP000000653};
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L.,
RA   Grills G., Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: Catalyzes the NAD-dependent conversion of D-erythrose 4-
CC       phosphate to 4-phosphoerythronate.
CC       {ECO:0000256|SAAS:SAAS00673677}.
CC   -!- CATALYTIC ACTIVITY: D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-
CC       phosphoerythronate + NADH. {ECO:0000256|SAAS:SAAS00673678}.
CC   -!- PATHWAY: Cofactor biosynthesis; pyridoxine 5'-phosphate
CC       biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-
CC       phosphate: step 1/5. {ECO:0000256|SAAS:SAAS00673679}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|SAAS:SAAS00680986}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00680987}.
CC   -!- SIMILARITY: Belongs to the glyceraldehyde-3-phosphate
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU000397,
CC       ECO:0000256|SAAS:SAAS00680993}.
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DR   EMBL; CP000438; ABJ15514.1; -; Genomic_DNA.
DR   RefSeq; WP_003084958.1; NC_008463.1.
DR   ProteinModelPortal; A0A0H2ZL79; -.
DR   SMR; A0A0H2ZL79; -.
DR   EnsemblBacteria; ABJ15514; ABJ15514; PA14_07170.
DR   KEGG; pau:PA14_07170; -.
DR   KO; K03472; -.
DR   OMA; MPQPRPY; -.
DR   UniPathway; UPA00244; UER00309.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0048001; F:erythrose-4-phosphate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0042823; P:pyridoxal phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0008615; P:pyridoxine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR006422; E4P_DH_bac.
DR   InterPro; IPR020831; GlycerAld/Erythrose_P_DH.
DR   InterPro; IPR020829; GlycerAld_3-P_DH_cat.
DR   InterPro; IPR020828; GlycerAld_3-P_DH_NAD(P)-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Pfam; PF02800; Gp_dh_C; 1.
DR   Pfam; PF00044; Gp_dh_N; 1.
DR   PIRSF; PIRSF000149; GAP_DH; 1.
DR   PRINTS; PR00078; G3PDHDRGNASE.
DR   SMART; SM00846; Gp_dh_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01532; E4PD_g-proteo; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0A0H2ZL79.
DR   SWISS-2DPAGE; A0A0H2ZL79.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000653};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00680989};
KW   NAD {ECO:0000256|SAAS:SAAS00680991};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00680996};
KW   Pyridoxine biosynthesis {ECO:0000256|SAAS:SAAS00673687}.
FT   DOMAIN        6    160       Gp_dh_N. {ECO:0000259|SMART:SM00846}.
FT   ACT_SITE    160    160       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000149-1}.
FT   SITE        187    187       Activates thiol group during catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR000149-4}.
SQ   SEQUENCE   353 AA;  38744 MW;  0B0378DA002FDE1F CRC64;
     MSTPPFRVAL NGYGRIGRCV LRALHERPEQ LGFEIVALND LADQASVEYL TRFDSTHGRF
     PGEVKVDGDC LHINGDCVKV LRSPTPEAID WQALRVDLVL ECSGQYTNRA QAERFLRAGA
     PRVLFSQPMA SEADIDATIV YGVNQQDLSG RETLVSNASC TTNCGVPLLK LLNEAIGLEY
     VSITTIHSAM NDQPVIDAYH HEDLRRTRSA FQSVIPVSTG LARGIERLLP ELAGRIQAKA
     IRVPTVNVSA LDITLQTSRD TSAAEINRVL REAAESGPLR GLLAYTELPH ASCDFNHDPH
     SAIVDGSQTR VSGPRLVNLL AWFDNEWGFA NRMLDVAGHY LRAAVPDQQV PKD
//

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