(data stored in ACNUC7421 zone)

SWISSPROT: ARLY_SYNFM

ID   ARLY_SYNFM              Reviewed;         466 AA.
AC   A0LEB1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 80.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006};
GN   OrderedLocusNames=Sfum_0060;
OS   Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Syntrophobacterales;
OC   Syntrophobacteraceae; Syntrophobacter.
OX   NCBI_TaxID=335543;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10017 / MPOB;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA   Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA   McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J.,
RA   Sieber J., Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT   "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC       arginine from L-ornithine and carbamoyl phosphate: step 3/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
DR   EMBL; CP000478; ABK15763.1; -; Genomic_DNA.
DR   RefSeq; WP_011696936.1; NC_008554.1.
DR   SMR; A0LEB1; -.
DR   STRING; 335543.Sfum_0060; -.
DR   PRIDE; A0LEB1; -.
DR   EnsemblBacteria; ABK15763; ABK15763; Sfum_0060.
DR   KEGG; sfu:Sfum_0060; -.
DR   eggNOG; ENOG4105CH7; Bacteria.
DR   eggNOG; COG0165; LUCA.
DR   HOGENOM; HOG000242744; -.
DR   KO; K01755; -.
DR   OMA; KKNPDVF; -.
DR   OrthoDB; 751464at2; -.
DR   BioCyc; SFUM335543:G1G7I-62-MONOMER; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000001784; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0LEB1.
DR   SWISS-2DPAGE; A0LEB1.
KW   Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome;
KW   Cytoplasm; Lyase; Reference proteome.
FT   CHAIN         1    466       Argininosuccinate lyase.
FT                                /FTId=PRO_1000057056.
SQ   SEQUENCE   466 AA;  52956 MW;  B9E7FD1B7BCBCDA5 CRC64;
     MTEKLWQGRF DQPTNRQVED YTASIHFDNR LYRYDIEGSI AHCRMLAQCK IISHDDASLI
     VQGLGEIRRE LERGKLHLGS SNEDIHMAIE QELMRKIGEV GGKLHTARSR NDQVALDVRL
     YMRDTLLQCR GLILQTQKVL VSCAEENLGV VMPGFTHLQH AQPILLSHHL MAYYEMLKRD
     DERFEQCFHR TNVLPLGSAA LAGTTFPIDM EWTAKYLNFP RVTSNSIDAV SDRDYLIEFG
     AASAMLMMHV SRLAEELILW SSTEFDFIEI SDAFCTGSSI MPQKKNPDVP ELMRGKTGRV
     YGNLMALLTL TKALPLAYNR DLQEDKEPVF DTADTIISTL RLLSRLIPEI RFHRERMGEM
     AIQGFTLATD LADYLVKKGV PFRKAHHIVG QIVQYCLKNR KQLHDCTVEE LKTFHKTIDQ
     DVFPFLEVAG AIDQRVSIGG TATTRVVEAI EKARAELDAL EQSLSS
//

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