(data stored in ACNUC7421 zone)

SWISSPROT: XERC_SYNFM

ID   XERC_SYNFM              Reviewed;         328 AA.
AC   A0LEB8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 75.
DE   RecName: Full=Tyrosine recombinase XerC {ECO:0000255|HAMAP-Rule:MF_01808};
GN   Name=xerC {ECO:0000255|HAMAP-Rule:MF_01808};
GN   OrderedLocusNames=Sfum_0067;
OS   Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Syntrophobacterales;
OC   Syntrophobacteraceae; Syntrophobacter.
OX   NCBI_TaxID=335543;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10017 / MPOB;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA   Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA   McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J.,
RA   Sieber J., Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT   "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by
CC       catalyzing the cutting and rejoining of the recombining DNA
CC       molecules. The XerC-XerD complex is essential to convert dimers of
CC       the bacterial chromosome into monomers to permit their segregation
CC       at cell division. It also contributes to the segregational
CC       stability of plasmids. {ECO:0000255|HAMAP-Rule:MF_01808}.
CC   -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC       molecules of XerC and two molecules of XerD. {ECO:0000255|HAMAP-
CC       Rule:MF_01808}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01808}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01808}.
DR   EMBL; CP000478; ABK15770.1; -; Genomic_DNA.
DR   SMR; A0LEB8; -.
DR   STRING; 335543.Sfum_0067; -.
DR   PRIDE; A0LEB8; -.
DR   EnsemblBacteria; ABK15770; ABK15770; Sfum_0067.
DR   KEGG; sfu:Sfum_0067; -.
DR   eggNOG; ENOG4105C13; Bacteria.
DR   eggNOG; COG4974; LUCA.
DR   HOGENOM; HOG000045294; -.
DR   KO; K03733; -.
DR   OMA; FASHMLE; -.
DR   Proteomes; UP000001784; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0LEB8.
DR   SWISS-2DPAGE; A0LEB8.
KW   Cell cycle; Cell division; Chromosome partition; Complete proteome;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding;
KW   Reference proteome.
FT   CHAIN         1    328       Tyrosine recombinase XerC.
FT                                /FTId=PRO_1000088247.
FT   ACT_SITE    171    171       {ECO:0000255|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    195    195       {ECO:0000255|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    267    267       {ECO:0000255|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    270    270       {ECO:0000255|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    293    293       {ECO:0000255|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    302    302       O-(3'-phospho-DNA)-tyrosine intermediate.
FT                                {ECO:0000255|HAMAP-Rule:MF_01808}.
SQ   SEQUENCE   328 AA;  36797 MW;  88E50D4B1ABFA91E CRC64;
     MAPGTLDDNS ADGSEATWSE ASARFIAHLR HERGLSAETV RAYAGDLDQF REHMNATAGT
     ADPRLSQVDA DAIRGYLAAL HKTRKKTSRA RKLSTLRSFY HFLNDRELVR ENPAALVAYP
     KLGTKIPSFL GVDDVFHLLD SLNAGAARAG ASWRRCRNWA LFECMYSTGV RVSELAGMDE
     SDVDFHEGMV RVLGKGSKER IVPVGGKALD AVKLYLRVLD SQFPEARRMG SALFRNARGR
     RLTTRSVHRL LRMELRRCGL WQHLSPHGLR HTFATHLLNS GADLRAIQEM LGHSNLSTTQ
     RYTHVHVDQL MKVYDAAHPR SRRDRSGK
//

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