(data stored in ACNUC7421 zone)

SWISSPROT: COBT_SYNFM

ID   COBT_SYNFM              Reviewed;         353 AA.
AC   A0LF21;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   11-DEC-2019, entry version 86.
DE   RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_00230};
DE            Short=NN:DBI PRT {ECO:0000255|HAMAP-Rule:MF_00230};
DE            EC=2.4.2.21 {ECO:0000255|HAMAP-Rule:MF_00230};
DE   AltName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_00230};
GN   Name=cobT {ECO:0000255|HAMAP-Rule:MF_00230}; OrderedLocusNames=Sfum_0323;
OS   Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Syntrophobacterales;
OC   Syntrophobacteraceae; Syntrophobacter.
OX   NCBI_TaxID=335543;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10017 / MPOB;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA   Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA   McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J.,
RA   Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT   "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from
CC       nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
CC       {ECO:0000255|HAMAP-Rule:MF_00230}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide =
CC         alpha-ribazole 5'-phosphate + H(+) + nicotinate;
CC         Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890,
CC         ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00230};
CC   -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-
CC       ribazole from 5,6-dimethylbenzimidazole: step 1/2. {ECO:0000255|HAMAP-
CC       Rule:MF_00230}.
CC   -!- SIMILARITY: Belongs to the CobT family. {ECO:0000255|HAMAP-
CC       Rule:MF_00230}.
DR   EMBL; CP000478; ABK16023.1; -; Genomic_DNA.
DR   RefSeq; WP_011697196.1; NC_008554.1.
DR   SMR; A0LF21; -.
DR   STRING; 335543.Sfum_0323; -.
DR   PRIDE; A0LF21; -.
DR   EnsemblBacteria; ABK16023; ABK16023; Sfum_0323.
DR   KEGG; sfu:Sfum_0323; -.
DR   eggNOG; ENOG4105CUP; Bacteria.
DR   eggNOG; COG2038; LUCA.
DR   HOGENOM; HOG000263499; -.
DR   KO; K00768; -.
DR   OMA; QMATFAE; -.
DR   OrthoDB; 1765140at2; -.
DR   BioCyc; SFUM335543:G1G7I-327-MONOMER; -.
DR   UniPathway; UPA00061; UER00516.
DR   Proteomes; UP000001784; Chromosome.
DR   GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009163; P:nucleoside biosynthetic process; IEA:InterPro.
DR   CDD; cd02439; DMB-PRT_CobT; 1.
DR   Gene3D; 1.10.1610.10; -; 1.
DR   Gene3D; 3.40.50.10210; -; 1.
DR   HAMAP; MF_00230; CobT; 1.
DR   InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase-like.
DR   InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N.
DR   InterPro; IPR017846; Nict_dMeBzImd_PRibTrfase_pro.
DR   InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf.
DR   Pfam; PF02277; DBI_PRT; 1.
DR   SUPFAM; SSF52733; SSF52733; 1.
DR   TIGRFAMs; TIGR03160; cobT_DBIPRT; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0LF21.
DR   SWISS-2DPAGE; A0LF21.
KW   Cobalamin biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..353
FT                   /note="Nicotinate-nucleotide--dimethylbenzimidazole
FT                   phosphoribosyltransferase"
FT                   /id="PRO_1000021638"
FT   ACT_SITE        319
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00230"
SQ   SEQUENCE   353 AA;  37072 MW;  0DDFCC4BEF4799E3 CRC64;
     MEKLDRLLER IEPASKDWEA KAWERLHAQI RPRDSLGRLE VIAARLAAIK RSLTPAVGRK
     IIFTMAGDHG VAAEGVSAYP QEVTAQMVGS FVRGWASINI LAVHCGAAVR VVDCGVASDL
     PPDWPVLRRK LGKGTANIAV GPAMSREVAV RGLTIGAEIV QDAHLKEGYL LFGTGDMGIG
     NTTPSTAIIA ALGGKPVRDL TGRGTGIDDV AFERKVRVIE RALAVNRPDP NDPLGVLAGV
     GGFEIAALGG AVLGAAALRV PIICDGFIAT AGALVACRLA PKAADYLFVS HRSREVGHTA
     MVDMLGMRPI LDLDMRLGEG TGSALAMNIV EAAAKVLVEC KTFEEAGVTD TGH
//

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