(data stored in ACNUC7421 zone)

SWISSPROT: A0KFQ7_AERHH

ID   A0KFQ7_AERHH            Unreviewed;       422 AA.
AC   A0KFQ7;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 93.
DE   RecName: Full=Mannitol-1-phosphate 5-dehydrogenase {ECO:0000256|HAMAP-Rule:MF_00196, ECO:0000256|SAAS:SAAS00314930};
DE            EC=1.1.1.17 {ECO:0000256|HAMAP-Rule:MF_00196, ECO:0000256|SAAS:SAAS00314928};
GN   Name=mtlD {ECO:0000256|HAMAP-Rule:MF_00196};
GN   OrderedLocusNames=AHA_0550 {ECO:0000313|EMBL:ABK36112.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK36112.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK36112.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-
CC         phosphate + H(+) + NADH; Xref=Rhea:RHEA:19661,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57634,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:61381; EC=1.1.1.17;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00196,
CC         ECO:0000256|SAAS:SAAS01118284};
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00196, ECO:0000256|SAAS:SAAS00540913}.
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DR   EMBL; CP000462; ABK36112.1; -; Genomic_DNA.
DR   RefSeq; WP_011704522.1; NC_008570.1.
DR   RefSeq; YP_855083.1; NC_008570.1.
DR   STRING; 380703.AHA_0550; -.
DR   EnsemblBacteria; ABK36112; ABK36112; AHA_0550.
DR   GeneID; 4488526; -.
DR   KEGG; aha:AHA_0550; -.
DR   PATRIC; fig|380703.7.peg.544; -.
DR   eggNOG; ENOG4107SQ3; Bacteria.
DR   eggNOG; COG0246; LUCA.
DR   HOGENOM; HOG000271391; -.
DR   KO; K00009; -.
DR   OMA; QHHEDPL; -.
DR   BioCyc; AHYD380703:G1G7B-551-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019594; P:mannitol metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   HAMAP; MF_00196; Mannitol_dehydrog; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR023028; Mannitol_1_phos_5_DH.
DR   InterPro; IPR000669; Mannitol_DH.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR023027; Mannitol_DH_CS.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KFQ7.
DR   SWISS-2DPAGE; A0KFQ7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_00196, ECO:0000256|SAAS:SAAS00314927};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00196,
KW   ECO:0000256|SAAS:SAAS00314933, ECO:0000313|EMBL:ABK36112.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756}.
FT   DOMAIN       42    164       Mannitol_dh. {ECO:0000259|Pfam:PF01232}.
FT   DOMAIN      191    412       Mannitol_dh_C. {ECO:0000259|Pfam:
FT                                PF08125}.
FT   NP_BIND      44     55       NAD. {ECO:0000256|HAMAP-Rule:MF_00196}.
SQ   SEQUENCE   422 AA;  46151 MW;  7FDFED78361B07D3 CRC64;
     MNPASSTGWP APRIPRSSWI CWVPNRLPDR PSSSLVQEVN IMKTLHFGAG NIGRGFIGKL
     LADASHQVTF ADVNETLIDQ LNHRQEYKVH VVGADQKLDV VRNVAAVSSA GHEVIARIIT
     ADLVTTAVGP NILDKIASTL AKGLQARFDA GNLTPLNVIA CENMVRGTSH LKQEVLKYLP
     VAYHATLDAC IGFVDSAVDR IVPPAAANDD PLEVTVESFS EWIVDQTQFK GELPQVAGME
     PTDNLMAFVE RKLFTLNTGH IVTAYLGKLR GYRTIREAIE DPLIRSKVRR AMEESGAVLV
     QRYGFDPRLH AAYIEKILAR FANPYLVDEI DRVGRQPLRK LAAGDRLVKP LLGTLEYGLP
     SDHLQEGIAA ALHYRNADDP QAVELQQLLA ELGPAQALAR ITGLAADSDI VSAIVTRYGN
     LK
//

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