(data stored in ACNUC7421 zone)

SWISSPROT: A0KR09_AERHH

ID   A0KR09_AERHH            Unreviewed;       359 AA.
AC   A0KR09;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 88.
DE   RecName: Full=Pyruvate kinase {ECO:0000256|RuleBase:RU000504};
DE            EC=2.7.1.40 {ECO:0000256|RuleBase:RU000504};
GN   Name=pyk-1 {ECO:0000313|EMBL:ABK36375.1};
GN   OrderedLocusNames=AHA_0029 {ECO:0000313|EMBL:ABK36375.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK36375.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK36375.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate;
CC         Xref=Rhea:RHEA:18157, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58702, ChEBI:CHEBI:456216;
CC         EC=2.7.1.40; Evidence={ECO:0000256|RuleBase:RU000504};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 5/5.
CC       {ECO:0000256|RuleBase:RU000504}.
CC   -!- SIMILARITY: Belongs to the pyruvate kinase family.
CC       {ECO:0000256|RuleBase:RU000504}.
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DR   EMBL; CP000462; ABK36375.1; -; Genomic_DNA.
DR   RefSeq; WP_011704069.1; NC_008570.1.
DR   RefSeq; YP_854554.1; NC_008570.1.
DR   STRING; 380703.AHA_0029; -.
DR   EnsemblBacteria; ABK36375; ABK36375; AHA_0029.
DR   GeneID; 4488991; -.
DR   KEGG; aha:AHA_0029; -.
DR   PATRIC; fig|380703.7.peg.24; -.
DR   eggNOG; ENOG4105CA9; Bacteria.
DR   eggNOG; COG0469; LUCA.
DR   HOGENOM; HOG000021558; -.
DR   KO; K00873; -.
DR   OMA; HTINVNY; -.
DR   BioCyc; AHYD380703:G1G7B-29-MONOMER; -.
DR   UniPathway; UPA00109; UER00188.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030955; F:potassium ion binding; IEA:InterPro.
DR   GO; GO:0004743; F:pyruvate kinase activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.40.33.10; -; 1.
DR   Gene3D; 3.20.20.60; -; 1.
DR   InterPro; IPR001697; Pyr_Knase.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   InterPro; IPR011037; Pyrv_Knase-like_insert_dom_sf.
DR   InterPro; IPR015793; Pyrv_Knase_brl.
DR   InterPro; IPR015806; Pyrv_Knase_insert_dom_sf.
DR   PANTHER; PTHR11817; PTHR11817; 1.
DR   Pfam; PF00224; PK; 1.
DR   PRINTS; PR01050; PYRUVTKNASE.
DR   SUPFAM; SSF50800; SSF50800; 1.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   TIGRFAMs; TIGR01064; pyruv_kin; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KR09.
DR   SWISS-2DPAGE; A0KR09.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   Glycolysis {ECO:0000256|RuleBase:RU000504};
KW   Kinase {ECO:0000256|RuleBase:RU000504, ECO:0000313|EMBL:ABK36375.1};
KW   Magnesium {ECO:0000256|RuleBase:RU000504};
KW   Pyruvate {ECO:0000313|EMBL:ABK36375.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW   Transferase {ECO:0000256|RuleBase:RU000504,
KW   ECO:0000313|EMBL:ABK36375.1}.
FT   DOMAIN        1    342       PK. {ECO:0000259|Pfam:PF00224}.
SQ   SEQUENCE   359 AA;  37766 MW;  1F97EB0614E5F21E CRC64;
     MRKTKIIATL GPASSSAAMV EQLIQAGANV FRLNFSHGSP EQHLALAARI RACAARLDRE
     IGILADLQGP KIRIASFADG CIRLQPGDPF TIDAGLDSHQ GDQSRVGTDY PALAGELQTG
     NVVLLDDGRI QLCVEQVIDE RIETRVLVGG TLSSRKGINV LGGGLSAPAL TDKDKADILT
     ARLLEADYIA VSFPRSAADL EEARTLIRAS GSRAAIVAKV ERAEVVASVA AMDELIHAAD
     LIMVARGDLG VEIGDARLPG VQKRLIRRCR ALGRPVITAT QMMESMIASP MPTRAEVMDV
     ANAVMDGSDA VMLSAESATG RYPVEAVAAM ARIALAAEQE MEPAGHGLAA SHGELARLA
//

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