(data stored in ACNUC7421 zone)

SWISSPROT: A0KEZ6_AERHH

ID   A0KEZ6_AERHH            Unreviewed;       690 AA.
AC   A0KEZ6;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 85.
DE   RecName: Full=ATP-dependent DNA helicase RecG {ECO:0000256|RuleBase:RU363016};
DE            EC=3.6.4.12 {ECO:0000256|RuleBase:RU363016};
GN   Name=recG {ECO:0000256|RuleBase:RU363016,
GN   ECO:0000313|EMBL:ABK36805.1};
GN   OrderedLocusNames=AHA_0284 {ECO:0000313|EMBL:ABK36805.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK36805.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK36805.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Critical role in recombination and DNA repair. Helps
CC       process Holliday junction intermediates to mature products by
CC       catalyzing branch migration. Has a DNA unwinding activity
CC       characteristic of a DNA helicase with a 3'- to 5'- polarity.
CC       Unwinds branched duplex DNA (Y-DNA).
CC       {ECO:0000256|RuleBase:RU363016}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|RuleBase:RU363016};
CC   -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC       {ECO:0000256|RuleBase:RU363016}.
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DR   EMBL; CP000462; ABK36805.1; -; Genomic_DNA.
DR   RefSeq; WP_011704291.1; NC_008570.1.
DR   RefSeq; YP_854812.1; NC_008570.1.
DR   STRING; 380703.AHA_0284; -.
DR   EnsemblBacteria; ABK36805; ABK36805; AHA_0284.
DR   GeneID; 4490442; -.
DR   KEGG; aha:AHA_0284; -.
DR   PATRIC; fig|380703.7.peg.272; -.
DR   eggNOG; ENOG4105CB5; Bacteria.
DR   eggNOG; COG1200; LUCA.
DR   HOGENOM; HOG000036617; -.
DR   KO; K03655; -.
DR   OMA; RETNDGF; -.
DR   BioCyc; AHYD380703:G1G7B-285-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00079; HELICc; 1.
DR   InterPro; IPR004609; ATP-dep_DNA_helicase_RecG.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR033454; RecG_wedge.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF17191; RecG_wedge; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00643; recG; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KEZ6.
DR   SWISS-2DPAGE; A0KEZ6.
KW   ATP-binding {ECO:0000256|RuleBase:RU363016};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   DNA damage {ECO:0000256|RuleBase:RU363016};
KW   DNA recombination {ECO:0000256|RuleBase:RU363016};
KW   DNA repair {ECO:0000256|RuleBase:RU363016};
KW   Helicase {ECO:0000256|RuleBase:RU363016, ECO:0000313|EMBL:ABK36805.1};
KW   Hydrolase {ECO:0000256|RuleBase:RU363016,
KW   ECO:0000313|EMBL:ABK36805.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU363016};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756}.
FT   DOMAIN      281    446       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      479    625       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
SQ   SEQUENCE   690 AA;  75922 MW;  7EAB726D1EB318E9 CRC64;
     MMKLDKISLD SLKGVGSKMQ EKLERLGLAT VQDLLFHLPL RYEDRTQVWP IGDLPPGLHG
     AVEGEIQDTQ LVMGRRRMLV CRISDGTGTL TLRFFNFTAA QKNSLSPGRL MRCFGEVRPG
     KYGLEMAHPE YKLLGEEQAG QTEEALTPVY PTTEGLRQLT LRSLTDQALA QLDLYGVEEL
     LPAGLYPQQI DLAAALKLLH RPPPSVALAL LESGQHPAQQ RLVLEELLAH NLSVLKVRAQ
     AQTQLARALK PAPALVEQLL GALPFTPTGA QNRVVAEIGR DLQQSHPMMR LVQGDVGSGK
     TLVAALAALQ AIGNGCQVGL MAPTELLAEQ HAINFAKWLE PLGIGVGWLA GKQKGKAREE
     ALAAIADGSV KMVVGTHAIF QEQVVFQRLA LVIIDEQHRF GVHQRLALRE KGEREGVHPH
     QLIMTATPIP RTLAMTAYAD LDTSIIDELP PGRTPITTVA LPDSRRQDVI ERVRLACEEG
     KQAYWVCTLI EESEVLECQA AEDTAAELQN LLPGLHIGLV HGRMRPVEKQ RVMEEFKAGM
     LQLLVATTVI EVGVDVPNAS LMIIENPERL GLAQLHQLRG RVGRGSVASH CVLLYHAPLS
     KTAQSRLGVL RETNDGFLIA QRDLELRGPG ELLGTRQTGL ADLKIADLVR DQPLIPQVQK
     MARFLMDRHP SHVEPLIRRW LGLRDHYSNA
//

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