(data stored in ACNUC7421 zone)

SWISSPROT: A0KER7_AERHH

ID   A0KER7_AERHH            Unreviewed;      1024 AA.
AC   A0KER7;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 85.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU361154, ECO:0000256|SAAS:SAAS01166384};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU361154, ECO:0000256|SAAS:SAAS01166384};
DE   AltName: Full=Lactase {ECO:0000256|RuleBase:RU361154};
GN   OrderedLocusNames=AHA_0205 {ECO:0000313|EMBL:ABK37231.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK37231.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK37231.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU361154,
CC         ECO:0000256|SAAS:SAAS01166382};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC       {ECO:0000256|RuleBase:RU361154, ECO:0000256|SAAS:SAAS00568376}.
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DR   EMBL; CP000462; ABK37231.1; -; Genomic_DNA.
DR   RefSeq; WP_011704217.1; NC_008570.1.
DR   RefSeq; YP_854732.1; NC_008570.1.
DR   STRING; 380703.AHA_0205; -.
DR   CAZy; GH2; Glycoside Hydrolase Family 2.
DR   EnsemblBacteria; ABK37231; ABK37231; AHA_0205.
DR   GeneID; 4489089; -.
DR   KEGG; aha:AHA_0205; -.
DR   PATRIC; fig|380703.7.peg.192; -.
DR   eggNOG; ENOG4105CNT; Bacteria.
DR   eggNOG; COG3250; LUCA.
DR   HOGENOM; HOG000252444; -.
DR   KO; K12111; -.
DR   OMA; WCDHGIL; -.
DR   BioCyc; AHYD380703:G1G7B-206-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 2.70.98.10; -; 1.
DR   InterPro; IPR004199; B-gal_small/dom_5.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   InterPro; IPR006101; Glyco_hydro_2.
DR   InterPro; IPR023232; Glyco_hydro_2_AS.
DR   InterPro; IPR023933; Glyco_hydro_2_beta_Galsidase.
DR   InterPro; IPR006103; Glyco_hydro_2_cat.
DR   InterPro; IPR023230; Glyco_hydro_2_CS.
DR   InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR   InterPro; IPR006104; Glyco_hydro_2_N.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR032312; LacZ_4.
DR   PANTHER; PTHR46323; PTHR46323; 1.
DR   Pfam; PF02929; Bgal_small_N; 1.
DR   Pfam; PF16353; DUF4981; 1.
DR   Pfam; PF00703; Glyco_hydro_2; 1.
DR   Pfam; PF02836; Glyco_hydro_2_C; 1.
DR   Pfam; PF02837; Glyco_hydro_2_N; 1.
DR   PRINTS; PR00132; GLHYDRLASE2.
DR   SMART; SM01038; Bgal_small_N; 1.
DR   SUPFAM; SSF49303; SSF49303; 2.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
DR   PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR   PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KER7.
DR   SWISS-2DPAGE; A0KER7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   Glycosidase {ECO:0000256|RuleBase:RU361154,
KW   ECO:0000256|SAAS:SAAS00422512, ECO:0000313|EMBL:ABK37231.1};
KW   Hydrolase {ECO:0000256|RuleBase:RU361154,
KW   ECO:0000256|SAAS:SAAS00422513, ECO:0000313|EMBL:ABK37231.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756}.
FT   DOMAIN      727    998       Bgal_small_N. {ECO:0000259|SMART:
FT                                SM01038}.
SQ   SEQUENCE   1024 AA;  117273 MW;  6BF9F23C919079C6 CRC64;
     MNNWENVQFV GENRLAPRAY FFSYADHALA ATMQRELSRR FLSLSGQWQF HYFDHPLQVP
     EAFYHSPMSE WDQITVPNMW QMEGHGQLQY TDEGFPFPID VPFVPTNNPT GAYQRSFTLS
     QAWDGEQVII KFDGVETYFE VYVNGHYIGF SKGSRLTAEF DISAYAKVGE NLLSVRVMQW
     ADSTYIEDQD MWWMAGIFRD VYLVGKPAAH VQDFFIRTAL ADDNQSATLS CDIQLENLGA
     AARDHRLVWS LLDQGSEIAS GSLDHLAIDG KCDCRFTLDL ANPHLWSAED PYLYQLQLSL
     YNGQGELLEV IPQRVGVREI KVKDGLFYVN GHYLKLHGVN RHDNDHLKSR AVGMDRVERD
     IVLMKQHNLN SVRTAHYPND PRFYELCDQY GLFVMAETDV ETHGFANVGD LSRITDDPFW
     EPVFVDRIER HVHAQKNHPS IIIWSLGNES GYGCNIRAMY RRCKQMDPTR LVHYEEDRDA
     EVVDLVSTMY SRVSQMNCFG EFPMPKPRIL CEYAHAMGNG PGGLSEYQQV FDRHPHIQGH
     YIWEWCDHGI LDQDEQGRPV YKYGGDYGDY PNNYNFCMDG LIYPDQTPGP GLREYKQVIC
     PVKVRALDLA SGKLEVENRY WFSNLDDIRL LVEVKAEGEL LASQQIRLEG VAPGATTELQ
     LELPSLDGRE TFVQLRVIKA TATRYSAAEH ELGQYQFQLK ESTRQLQPFA NPNATALQIA
     DERLALTLSG SGFALRFSRL DGKLVSWQQD GNELIERAPR LTFFKPMIDN HKQEYESLWH
     PNHLQIMQEH FRTLSWRQLG EVVEVTVESL IAPPVFDFGM RCRYVYTLSP NGQLHVALSG
     QPYGGYDDII PKIGFELGIR QDLDRVHYYG MGPGENYQDS RQSNWIDSFQ STVGEMWEHY
     PFPQDNGNRQ QVRWATLTNR HGAGLYVRPD APINLSVWPY SWEHIHAAQH INELEPSGYL
     TLNLDHKVLG LGSNSWGSEV LDSWRVRFEP FSFGLTLLPI ARGNLNPAAL AGLDLTINGG
     RNLA
//

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