(data stored in ACNUC7421 zone)

SWISSPROT: A0KEY6_AERHH

ID   A0KEY6_AERHH            Unreviewed;       472 AA.
AC   A0KEY6;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 105.
DE   RecName: Full=DNA-binding transcriptional regulator NtrC {ECO:0000256|RuleBase:RU365013};
DE   AltName: Full=Nitrogen regulation protein NR(I) {ECO:0000256|RuleBase:RU365013};
GN   Name=ntrC {ECO:0000256|RuleBase:RU365013,
GN   ECO:0000313|EMBL:ABK37436.1};
GN   OrderedLocusNames=AHA_0274 {ECO:0000313|EMBL:ABK37436.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK37436.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK37436.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Member of the two-component regulatory system NtrB/NtrC,
CC       which controls expression of the nitrogen-regulated (ntr) genes in
CC       response to nitrogen limitation. Phosphorylated NtrC binds
CC       directly to DNA and stimulates the formation of open promoter-
CC       sigma54-RNA polymerase complexes. {ECO:0000256|RuleBase:RU365013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU365013}.
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DR   EMBL; CP000462; ABK37436.1; -; Genomic_DNA.
DR   RefSeq; WP_010635441.1; NC_008570.1.
DR   RefSeq; YP_854802.1; NC_008570.1.
DR   STRING; 380703.AHA_0274; -.
DR   EnsemblBacteria; ABK37436; ABK37436; AHA_0274.
DR   GeneID; 4490205; -.
DR   KEGG; aha:AHA_0274; -.
DR   PATRIC; fig|380703.7.peg.262; -.
DR   eggNOG; ENOG4105C1W; Bacteria.
DR   eggNOG; COG2204; LUCA.
DR   HOGENOM; HOG000058489; -.
DR   KO; K07712; -.
DR   OMA; DWTGNIR; -.
DR   BioCyc; AHYD380703:G1G7B-275-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR   GO; GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
DR   GO; GO:0006808; P:regulation of nitrogen utilization; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00156; REC; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR002078; Sigma_54_int.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR   InterPro; IPR025944; Sigma_54_int_dom_CS.
DR   InterPro; IPR010114; Trancript_reg_NtrC.
DR   Pfam; PF02954; HTH_8; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   PRINTS; PR01590; HTHFIS.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01818; ntrC; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR   PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR   PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR   PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR   PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE   4: Predicted;
DR   PRODOM; A0KEY6.
DR   SWISS-2DPAGE; A0KEY6.
KW   Activator {ECO:0000256|RuleBase:RU365013};
KW   ATP-binding {ECO:0000256|RuleBase:RU365013,
KW   ECO:0000256|SAAS:SAAS00473007}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   Cytoplasm {ECO:0000256|RuleBase:RU365013};
KW   DNA-binding {ECO:0000256|RuleBase:RU365013,
KW   ECO:0000256|SAAS:SAAS00421512};
KW   Nitrogen fixation {ECO:0000256|RuleBase:RU365013};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU365013,
KW   ECO:0000256|SAAS:SAAS00473126};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW   Repressor {ECO:0000256|RuleBase:RU365013};
KW   Transcription {ECO:0000256|RuleBase:RU365013,
KW   ECO:0000256|SAAS:SAAS00814760};
KW   Transcription regulation {ECO:0000256|RuleBase:RU365013,
KW   ECO:0000256|SAAS:SAAS00814754};
KW   Two-component regulatory system {ECO:0000256|RuleBase:RU365013}.
FT   DOMAIN        4    118       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   DOMAIN      141    370       Sigma-54 factor interaction.
FT                                {ECO:0000259|PROSITE:PS50045}.
FT   COILED      107    134       {ECO:0000256|SAM:Coils}.
FT   MOD_RES      53     53       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   472 AA;  52784 MW;  1E4B442363808EDE CRC64;
     MTAKVWIVDD DSSIRWVLER TLGSEGFECE SFADGEALLS SLEMRSPDVI LSDIRMPGID
     GLSLLEQIHR RQADLPIIIM TAHSDLDSAV NAYQRGAFEY LPKPFDIDEA VTLVRRAENH
     LKEQRTKRKA RQQDPASSPE IIGEAPAMQE VFRAIGRLSR SSISVLINGQ SGTGKELVAH
     ALHKHSPRAH KNFIALNMAA IPKDLIESEL FGHEKGAFTG ANNIRHGRFE QADGGTLFLD
     EIGDMPLDVQ TRLLRVLADG QFYRVGGHQP VQVDVRIIAA THQNLEKRVA DGEFREDLFH
     RLNVIRIHIP ALKERREDIP QLAQHFLLRA AKELNVEAKS LHPDTQAYIS RLPWPGNVRQ
     LENVCRWLTV MASGQEVLVS DLPTELLTPI TSTAEPGQPA LSGGWQQQLQ DWVAAKLALG
     ETDILADALP QFERIMLETA LDHTHGHKQE AARLLGWGRN TLTRKLKELD LS
//

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