(data stored in ACNUC7421 zone)

SWISSPROT: A0KEC7_AERHH

ID   A0KEC7_AERHH            Unreviewed;       237 AA.
AC   A0KEC7;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   11-DEC-2019, entry version 79.
DE   RecName: Full=3-deoxy-D-manno-octulosonic acid kinase {ECO:0000256|HAMAP-Rule:MF_00521};
DE            Short=Kdo kinase {ECO:0000256|HAMAP-Rule:MF_00521};
DE            EC=2.7.1.166 {ECO:0000256|HAMAP-Rule:MF_00521};
GN   Name=kdkA {ECO:0000256|HAMAP-Rule:MF_00521,
GN   ECO:0000313|EMBL:ABK37483.1};
GN   OrderedLocusNames=AHA_0043 {ECO:0000313|EMBL:ABK37483.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM
OS   1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK37483.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK37483.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.,
RA   Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA   Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-
CC       manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH
CC       position. {ECO:0000256|HAMAP-Rule:MF_00521}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-
CC         (2->6)-lipid IVA + ADP + H(+); Xref=Rhea:RHEA:28506,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:60364,
CC         ChEBI:CHEBI:61589, ChEBI:CHEBI:456216; EC=2.7.1.166;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00521};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00521}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_00521}; Peripheral membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_00521}; Cytoplasmic side {ECO:0000256|HAMAP-Rule:MF_00521}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. KdkA/RfaP
CC       family. {ECO:0000256|HAMAP-Rule:MF_00521}.
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DR   EMBL; CP000462; ABK37483.1; -; Genomic_DNA.
DR   RefSeq; WP_011704082.1; NC_008570.1.
DR   RefSeq; YP_854568.1; NC_008570.1.
DR   STRING; 380703.AHA_0043; -.
DR   EnsemblBacteria; ABK37483; ABK37483; AHA_0043.
DR   GeneID; 4490263; -.
DR   KEGG; aha:AHA_0043; -.
DR   PATRIC; fig|380703.7.peg.38; -.
DR   eggNOG; ENOG4108W7E; Bacteria.
DR   eggNOG; COG0515; LUCA.
DR   HOGENOM; HOG000269423; -.
DR   KO; K11211; -.
DR   OMA; RGGLWGK; -.
DR   BioCyc; AHYD380703:G1G7B-43-MONOMER; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00521; KDO_kinase; 1.
DR   InterPro; IPR022826; KDO_kinase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KEC7.
DR   SWISS-2DPAGE; A0KEC7.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00521};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00521};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00521};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00521, ECO:0000313|EMBL:ABK37483.1};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00521};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00521};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00521};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00521, ECO:0000313|EMBL:ABK37483.1}.
FT   DOMAIN          36..237
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   ACT_SITE        166
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00521"
SQ   SEQUENCE   237 AA;  27194 MW;  0256652CBC65AB45 CRC64;
     MQIQTEHNQI CWYAEGAFRD PSPELFDPAW WQTHRQVVGS SIGRGVTWFV KDESRHLVLR
     HYYRGGMVGK VVRDRFWFEG VESSRAMAEY TLLAKLSAQG LPVPRPFAAR MAKQGPFYRA
     DILIERIRGA KDLVALLKQG PIAGEVWHKV GQTVRRLHDA GVYHADLNSH NLLLDKEGKV
     WVIDFDKGAI RSPGNWQQAN LERLLRSFNK ESQLHTSFHF VPENWQALMN GYQGKAS
//

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