(data stored in ACNUC7421 zone)

SWISSPROT: A0KFQ5_AERHH

ID   A0KFQ5_AERHH            Unreviewed;       651 AA.
AC   A0KFQ5;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   11-DEC-2019, entry version 88.
DE   SubName: Full=Sodium/hydrogen exchanger family protein {ECO:0000313|EMBL:ABK37889.1};
GN   OrderedLocusNames=AHA_0548 {ECO:0000313|EMBL:ABK37889.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM
OS   1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK37889.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK37889.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.,
RA   Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA   Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. {ECO:0000256|SAAS:SAAS01092086}.
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DR   EMBL; CP000462; ABK37889.1; -; Genomic_DNA.
DR   RefSeq; WP_011704521.1; NC_008570.1.
DR   RefSeq; YP_855081.1; NC_008570.1.
DR   STRING; 380703.AHA_0548; -.
DR   EnsemblBacteria; ABK37889; ABK37889; AHA_0548.
DR   GeneID; 4488524; -.
DR   KEGG; aha:AHA_0548; -.
DR   PATRIC; fig|380703.7.peg.542; -.
DR   eggNOG; ENOG4108EKG; Bacteria.
DR   eggNOG; COG0025; LUCA.
DR   HOGENOM; HOG000271369; -.
DR   OMA; KWEGILI; -.
DR   BioCyc; AHYD380703:G1G7B-549-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51201; RCK_N; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KFQ5.
DR   SWISS-2DPAGE; A0KFQ5.
KW   Antiport {ECO:0000256|SAAS:SAAS01092098};
KW   Ion transport {ECO:0000256|SAAS:SAAS01092081};
KW   Membrane {ECO:0000256|SAAS:SAAS01092093, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01092090, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01092105,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS01092095}.
FT   TRANSMEM        49..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        79..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        110..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        171..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        246..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        386..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        419..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          454..561
FT                   /note="RCK N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51201"
SQ   SEQUENCE   651 AA;  69447 MW;  0ACFCD7787F81302 CRC64;
     MAAVSGHTPP LSRGHAPVTP AVARSASPLV PAADWCQSDH LPHYTSSRFI ALIEVCMIAL
     SLAGIALVSV LAQWLAWSLR VPAILFLLLT GLLLGPVSGL LDPDALLGDL LFPLVSLSVA
     IILFEGALTL HLAELKGIGK VVRNLCSVGM LASFAVIGSA GYFLLGLDWR VAMVLGAVLV
     VTGPTVVAPM LNVIRPTREV DRILRWEGIV IDPIGALFAV LVFEAVRLGS QGDLIGHTLL
     ALAKTVGVGS LIGVGAGWLT TLLIRKDWLP VSLHKFGVLA LVLVTFSLSN WLSHESGLLA
     VTVFGIWLAN QEGLDLEEVL AFKEDLAVIL ISSLFILLAA RLDLAQLWQL GPMVLALLCV
     VQFVARPLCI LVSTWGSDLS WRARALLGWI APRGIVAAAV SASFAISLHQ AGIPDADKLV
     PLVFAVIIST VVLQSLTSAP LAGLLKMRQS APNTWLIIGA NSVARAIGKA LADQGVPVQL
     CDPAWEFCKQ ARMSNLPCYF GNPQSEHAEL HLPLTSISTV LALSPNRHNN ALGVLHFAHL
     YGEEKVYSLR SSEQHGKANR ESATFRARQN LFGPDINYAR LSGLLSRGGQ IKATRLSEAF
     DWTQYQEANP GAIPLFVLDG KGRARIVTGP VEPLAGELLI ALQPPKETAT P
//

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