(data stored in ACNUC7421 zone)

SWISSPROT: A0KR18_AERHH

ID   A0KR18_AERHH            Unreviewed;       665 AA.
AC   A0KR18;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 96.
DE   SubName: Full=Sensor histidine kinase {ECO:0000313|EMBL:ABK38225.1};
GN   OrderedLocusNames=AHA_0020 {ECO:0000313|EMBL:ABK38225.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK38225.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK38225.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; CP000462; ABK38225.1; -; Genomic_DNA.
DR   RefSeq; WP_011704064.1; NC_008570.1.
DR   RefSeq; YP_854549.1; NC_008570.1.
DR   STRING; 380703.AHA_0020; -.
DR   EnsemblBacteria; ABK38225; ABK38225; AHA_0020.
DR   GeneID; 4488982; -.
DR   KEGG; aha:AHA_0020; -.
DR   PATRIC; fig|380703.7.peg.19; -.
DR   eggNOG; ENOG4105BZU; Bacteria.
DR   eggNOG; ENOG410XNMH; LUCA.
DR   HOGENOM; HOG000285142; -.
DR   OMA; QWIMEND; -.
DR   BioCyc; AHYD380703:G1G7B-20-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR033414; Sensor_dom.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF17149; CHASE5; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; A0KR18.
DR   SWISS-2DPAGE; A0KR18.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:ABK38225.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     31     53       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    164    189       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      187    246       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      432    664       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   COILED      371    391       {ECO:0000256|SAM:Coils}.
FT   COILED      396    416       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   665 AA;  75059 MW;  16130CABE2EE6816 CRC64;
     MAIYPDRKDA MSGLFSKTAK AVGRNGLSYR LLSYILVCST VLAMIITVLQ LAWDYRKDVA
     VIEDSIGQIE ASFLQPIAAS LWNLDEEQVK VQIEGIMNLP NMQFVMVKEM LGNSEVPLLT
     QGVERESYDI SREFNLTYQG EVVGKLFVAA SLEQIYQRLI EKSVLIMVSQ TIKTLVVSFC
     ILIIIYYLVV RHLNRIANYA QKFNLDRLAI ELTLEGRPLP RKKPDELDTL VATLNQMRTR
     LNDEFAARHQ AAEQLQQERD FSATLINSAN MVICCMEPDL NIASINPAAI LLTGYHQQEI
     LQHNWLDLFV SKAQRDELAA TLADHGSIED KEVIMHDQQG HELVLQWTFA PFYEGPNLKY
     LIGFGYDITR LKKVEREIIQ LNEQLEGKVV ERTRSLSDAN DQLGKAYDDL KQAQQTLVES
     EKMASLGSLV AGVAHEINTP IGISVTASSY LQERVADFKQ HIDSKQLSRS YLTEFTVNLD
     ESMQLLQGNL RRASELIASF KQVAVDQSSE ARYNFSLADN LHQVVVSLGH KLKKAQCEVD
     IQCDPKLSIF SFPGSFTQIY SNLILNSINH GFDNWDKPKK ITIKVEQQGE ELLIDYSDNG
     RGIPPEILPR IFDPFVTSKR GQGGSGLGTH IIYNLVVQLL RGRINCVSEP DNGAQFHIRL
     PIQHN
//

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