(data stored in ACNUC7421 zone)

SWISSPROT: NFUA_AERHH

ID   NFUA_AERHH              Reviewed;         192 AA.
AC   A0KF09;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 74.
DE   RecName: Full=Fe/S biogenesis protein NfuA {ECO:0000255|HAMAP-Rule:MF_01637};
GN   Name=nfuA {ECO:0000255|HAMAP-Rule:MF_01637};
GN   OrderedLocusNames=AHA_0297;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240;
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-
CC       4S cluster, can transfer this cluster to apoproteins, and thereby
CC       intervenes in the maturation of Fe/S proteins. Could also act as a
CC       scaffold/chaperone for damaged Fe/S proteins. {ECO:0000255|HAMAP-
CC       Rule:MF_01637}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01637};
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. The cluster is
CC       presumably bound at the interface of two monomers.
CC       {ECO:0000255|HAMAP-Rule:MF_01637};
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01637}.
CC   -!- SIMILARITY: Belongs to the NfuA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01637}.
DR   EMBL; CP000462; ABK38584.1; -; Genomic_DNA.
DR   RefSeq; WP_011704302.1; NC_008570.1.
DR   RefSeq; YP_854827.1; NC_008570.1.
DR   SMR; A0KF09; -.
DR   STRING; 380703.AHA_0297; -.
DR   EnsemblBacteria; ABK38584; ABK38584; AHA_0297.
DR   GeneID; 4488756; -.
DR   KEGG; aha:AHA_0297; -.
DR   PATRIC; fig|380703.7.peg.285; -.
DR   eggNOG; ENOG4107RUK; Bacteria.
DR   eggNOG; COG0316; LUCA.
DR   eggNOG; COG0694; LUCA.
DR   HOGENOM; HOG000137052; -.
DR   KO; K07400; -.
DR   OMA; ETCLAYC; -.
DR   BioCyc; AHYD380703:G1G7B-298-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0051604; P:protein maturation; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.300.12; -; 1.
DR   Gene3D; 3.30.300.130; -; 1.
DR   HAMAP; MF_01637; Fe_S_biogen_NfuA; 1.
DR   InterPro; IPR017726; Fe/S_biogenesis_protein_NfuA.
DR   InterPro; IPR000361; FeS_biogenesis.
DR   InterPro; IPR034904; FSCA_dom_sf.
DR   InterPro; IPR035903; HesB-like_dom_sf.
DR   InterPro; IPR001075; NIF_FeS_clus_asmbl_NifU_C.
DR   Pfam; PF01521; Fe-S_biosyn; 1.
DR   Pfam; PF01106; NifU; 1.
DR   ProDom; PD002830; NIF_FeS_clus_asmbl_NifU_C; 1.
DR   SUPFAM; SSF117916; SSF117916; 1.
DR   SUPFAM; SSF89360; SSF89360; 1.
DR   TIGRFAMs; TIGR03341; YhgI_GntY; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KF09.
DR   SWISS-2DPAGE; A0KF09.
KW   4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding;
KW   Reference proteome.
FT   CHAIN         1    192       Fe/S biogenesis protein NfuA.
FT                                /FTId=PRO_0000292087.
FT   METAL       149    149       Iron-sulfur (4Fe-4S). {ECO:0000255|HAMAP-
FT                                Rule:MF_01637}.
FT   METAL       152    152       Iron-sulfur (4Fe-4S). {ECO:0000255|HAMAP-
FT                                Rule:MF_01637}.
SQ   SEQUENCE   192 AA;  20988 MW;  AF60A38A32EDB56A CRC64;
     MISISDTAQA HFRKLLEKQP DGTNIRVFVV NPGTQNAECG VSYCPPDAVD PEDQHLPFSG
     FDCLVDPLSA PFLVDATIDF VTDQMGSQLT LKAPNAKMRK VADDAPLIDR IEYVLMSEVN
     PMLAGHGGKV TLVELTEDKL AILQFGGGCN GCSMVDYTLK EGIEKQLLEK FPGELNGVKD
     ATEHQRGDHS YY
//

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