(data stored in ACNUC7421 zone)

SWISSPROT: A0KF78_AERHH

ID   A0KF78_AERHH            Unreviewed;       633 AA.
AC   A0KF78;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 93.
DE   RecName: Full=Signal recognition particle receptor FtsY {ECO:0000256|HAMAP-Rule:MF_00920};
DE            Short=SRP receptor {ECO:0000256|HAMAP-Rule:MF_00920};
GN   Name=ftsY {ECO:0000256|HAMAP-Rule:MF_00920};
GN   OrderedLocusNames=AHA_0371 {ECO:0000313|EMBL:ABK38711.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK38711.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK38711.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC       proteins into the cytoplasmic membrane. Acts as a receptor for the
CC       complex formed by the signal recognition particle (SRP) and the
CC       ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to
CC       the transfer of the RNC complex to the Sec translocase for
CC       insertion into the membrane, the hydrolysis of GTP by both Ffh and
CC       FtsY, and the dissociation of the SRP-FtsY complex into the
CC       individual components. {ECO:0000256|HAMAP-Rule:MF_00920}.
CC   -!- SUBUNIT: Part of the signal recognition particle protein
CC       translocation system, which is composed of SRP and FtsY. SRP is a
CC       ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.
CC       {ECO:0000256|HAMAP-Rule:MF_00920}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_00920}; Peripheral membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_00920}; Cytoplasmic side {ECO:0000256|HAMAP-
CC       Rule:MF_00920}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00920}.
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. FtsY subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00920}.
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DR   EMBL; CP000462; ABK38711.1; -; Genomic_DNA.
DR   RefSeq; WP_011704348.1; NC_008570.1.
DR   RefSeq; YP_854900.1; NC_008570.1.
DR   STRING; 380703.AHA_0371; -.
DR   EnsemblBacteria; ABK38711; ABK38711; AHA_0371.
DR   GeneID; 4490817; -.
DR   KEGG; aha:AHA_0371; -.
DR   PATRIC; fig|380703.7.peg.358; -.
DR   eggNOG; ENOG4105CCP; Bacteria.
DR   eggNOG; COG0552; LUCA.
DR   KO; K03110; -.
DR   OMA; GIEATDY; -.
DR   BioCyc; AHYD380703:G1G7B-372-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031226; C:intrinsic component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 1.20.120.140; -; 1.
DR   HAMAP; MF_00920; FtsY; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR   InterPro; IPR004390; SR_rcpt_FtsY.
DR   InterPro; IPR036225; SRP/SRP_N.
DR   InterPro; IPR000897; SRP54_GTPase_dom.
DR   InterPro; IPR042101; SRP54_N_sf.
DR   PANTHER; PTHR43134:SF7; PTHR43134:SF7; 1.
DR   Pfam; PF00448; SRP54; 1.
DR   Pfam; PF02881; SRP54_N; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00962; SRP54; 1.
DR   SMART; SM00963; SRP54_N; 1.
DR   SUPFAM; SSF47364; SSF47364; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00064; ftsY; 1.
DR   PROSITE; PS00300; SRP54; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KF78.
DR   SWISS-2DPAGE; A0KF78.
KW   Cell cycle {ECO:0000313|EMBL:ABK38711.1};
KW   Cell division {ECO:0000313|EMBL:ABK38711.1};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00920};
KW   GTP-binding {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Receptor {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756}.
FT   DOMAIN      603    616       SRP54. {ECO:0000259|PROSITE:PS00300}.
FT   NP_BIND     436    443       GTP. {ECO:0000256|HAMAP-Rule:MF_00920}.
FT   NP_BIND     518    522       GTP. {ECO:0000256|HAMAP-Rule:MF_00920}.
FT   NP_BIND     582    585       GTP. {ECO:0000256|HAMAP-Rule:MF_00920}.
FT   COILED       95    124       {ECO:0000256|SAM:Coils}.
FT   COILED      174    194       {ECO:0000256|SAM:Coils}.
FT   COILED      258    278       {ECO:0000256|SAM:Coils}.
FT   COILED      526    546       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   633 AA;  67297 MW;  2C01A9347F57D7BE CRC64;
     MAKGLFSWLG FGRKKEEAEA VQPQTPQATP ITAEPEVAAA PAPVSDPTPA VAAEVPASAQ
     NSVLHDDCCP PAELDDHGPL VVEECASDLE PVIVNEALLA EEERAAAQAQ AQEAARVAAE
     LKAAQEVRIA AEARAAEEAR IAAEARTAEE ARLAAEARAA EEARIAAEAR AAEEARLAAE
     ARAAEEARVA AEARAVKEAR IAAEASAAEE TRIAAEARAA EEARIAAEAR AAEEARLAAE
     ARAAEEARIA AEARAAEEAR LAAEARAAEE ARLAAEAQAA EEARLAKEAQ RVEDLRLVAE
     MEAEAAALAA LPLAAKVDDD TQEKPQREGF FARLKRSLVR TRENIGSGFF GLFRGKKIDD
     ELFEELETQL LTADLGVDTT SRIIEGLVQH ADRKQLKDAE ALYGLLKQDM GEMLAKVEQP
     LVIDTSKKPY VILMVGVNGV GKTTTIGKLA KQFQAEGKSV MLAAGDTFRA AAVEQLQVWG
     QRNNIPVIAQ HTGADSASVI YDAIEAARSR GADVLIADTA GRLQNKSNLM EELKKVVRVM
     KKLDDAAPHE IMLTLDAGTG QNALSQAKLF SEAVGLTGIT LTKLDGTAKG GVIFAVADKF
     QIPIRYIGVG EGIDDLRPFV ANDFIEALFS REE
//

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