SWISSPROT: A0KF16_AERHH

ID   A0KF16_AERHH            Unreviewed;       157 AA.
AC   A0KF16;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 96.
DE   RecName: Full=Transcription elongation factor GreB {ECO:0000256|HAMAP-Rule:MF_00930};
DE   AltName: Full=Transcript cleavage factor GreB {ECO:0000256|HAMAP-Rule:MF_00930};
GN   Name=greB {ECO:0000256|HAMAP-Rule:MF_00930,
GN   ECO:0000313|EMBL:ABK39100.1};
GN   OrderedLocusNames=AHA_0304 {ECO:0000313|EMBL:ABK39100.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK39100.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK39100.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting
CC       sites in DNA have the property of trapping a certain fraction of
CC       elongating RNA polymerases that pass through, resulting in locked
CC       ternary complexes. Cleavage of the nascent transcript by cleavage
CC       factors such as GreA or GreB allows the resumption of elongation
CC       from the new 3'terminus. GreB releases sequences of up to 9
CC       nucleotides in length. {ECO:0000256|HAMAP-Rule:MF_00930}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family. GreB subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00930}.
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DR   EMBL; CP000462; ABK39100.1; -; Genomic_DNA.
DR   RefSeq; WP_011704309.1; NC_008570.1.
DR   RefSeq; YP_854834.1; NC_008570.1.
DR   STRING; 380703.AHA_0304; -.
DR   EnsemblBacteria; ABK39100; ABK39100; AHA_0304.
DR   GeneID; 4488763; -.
DR   KEGG; aha:AHA_0304; -.
DR   PATRIC; fig|380703.7.peg.293; -.
DR   eggNOG; ENOG4108RRZ; Bacteria.
DR   eggNOG; COG0782; LUCA.
DR   HOGENOM; HOG000241145; -.
DR   KO; K04760; -.
DR   OMA; DQIFFGA; -.
DR   BioCyc; AHYD380703:G1G7B-305-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.180; -; 1.
DR   Gene3D; 3.10.50.30; -; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   HAMAP; MF_00930; GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR018151; TF_GreA/GreB_CS.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   InterPro; IPR006358; Tscrpt_elong_fac_GreB.
DR   PANTHER; PTHR30437; PTHR30437; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   PIRSF; PIRSF006092; GreA_GreB; 1.
DR   SUPFAM; SSF46557; SSF46557; 1.
DR   TIGRFAMs; TIGR01461; greB; 1.
DR   PROSITE; PS00830; GREAB_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KF16.
DR   SWISS-2DPAGE; A0KF16.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00930,
KW   ECO:0000256|SAAS:SAAS01033224};
KW   Elongation factor {ECO:0000313|EMBL:ABK39100.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:ABK39100.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00930,
KW   ECO:0000256|SAAS:SAAS01033216};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00930,
KW   ECO:0000256|SAAS:SAAS01033223}.
FT   DOMAIN        5     72       GreA_GreB_N. {ECO:0000259|Pfam:PF03449}.
FT   DOMAIN       81    155       GreA_GreB. {ECO:0000259|Pfam:PF01272}.
SQ   SEQUENCE   157 AA;  18624 MW;  F341F82BDA6BA758 CRC64;
     MKTKLITREG YNKLKQELDF LWREERPETT RKVAWAASLG DRSENADYQY NKKRLREIDR
     RVRYLRKCLE ELGIVDYSPA QEGKVFFGAW VEVENEEGET KRFRIVGYDE IFERKDYISI
     DSPMARALLK KEVGDEAIVR TPVGDACWYI NEISYPK
//