(data stored in ACNUC7421 zone)

SWISSPROT: A0KF61_AERHH

ID   A0KF61_AERHH            Unreviewed;       517 AA.
AC   A0KF61;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   11-DEC-2019, entry version 78.
DE   SubName: Full=Multidrug resistance protein B {ECO:0000313|EMBL:ABK39189.1};
GN   OrderedLocusNames=AHA_0354 {ECO:0000313|EMBL:ABK39189.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM
OS   1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK39189.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK39189.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.,
RA   Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA   Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS01209748}.
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DR   EMBL; CP000462; ABK39189.1; -; Genomic_DNA.
DR   RefSeq; WP_011704334.1; NC_008570.1.
DR   RefSeq; YP_854883.1; NC_008570.1.
DR   STRING; 380703.AHA_0354; -.
DR   EnsemblBacteria; ABK39189; ABK39189; AHA_0354.
DR   GeneID; 4489482; -.
DR   KEGG; aha:AHA_0354; -.
DR   PATRIC; fig|380703.7.peg.339; -.
DR   eggNOG; ENOG4105C0R; Bacteria.
DR   eggNOG; ENOG410XNN3; LUCA.
DR   HOGENOM; HOG000112189; -.
DR   KO; K03446; -.
DR   OMA; GNKKGWL; -.
DR   BioCyc; AHYD380703:G1G7B-355-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001411; Tet-R_TetB/Drug-R_transptr.
DR   PANTHER; PTHR23501; PTHR23501; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KF61.
DR   SWISS-2DPAGE; A0KF61.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00089479};
KW   Membrane {ECO:0000256|SAAS:SAAS00461656, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00461646, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00461653,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00089612}.
FT   TRANSMEM        9..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        77..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        102..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        136..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        194..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        225..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        267..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        332..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        400..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        484..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          11..507
FT                   /note="MFS"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
SQ   SEQUENCE   517 AA;  56447 MW;  49932780D8F5D613 CRC64;
     MEPIPRRNWI AVMGGLIGAF MAILDIQITN ASLKDIQGAL SATLSESSWI STSYLVAEMI
     AIPLSGWLSR GLSVRRYLLW TTGAFIVASV LCSFSWNLTS MIVFRALQGF TGGALIPMAF
     SLIVSLLPLH KRATGMALFG LCATFAPAIG PTLGGWLTEQ MSWHYIFYMN VPPGLLVMAM
     LAHGLDKKPV DWEVIKRVDL IGIVTMAVGL GLLEVVLEEG NREDWFGSSF IVRLTVISVV
     ALVFFVISQL LRRHPLVNLR LLHNPRFALA CFAYLVLGMA LMGSIYVLPL YMTQIHNYNA
     LEIGEVLMWM GLPQLLVLPL VPRLTHKIDP RYLVSFGFLV FAVSCFMNMN MSADYAGPQL
     IQSLIVRALG QPFIMVPLSL VATASLTHDE IPSSSTLLNV LRNLGGAFGI AIIATLIDND
     TRIHVSQISS TLAASSIEGQ SYLLQLAQTM MAQGSGPELA RQQAQAMLSN TISREAAIMA
     YNQVFFVMGI FLLLASGLML LLKQPAPRAA DAEPLEA
//

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