(data stored in ACNUC7421 zone)

SWISSPROT: A0KEE6_AERHH

ID   A0KEE6_AERHH            Unreviewed;       611 AA.
AC   A0KEE6;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   08-MAY-2019, entry version 86.
DE   RecName: Full=Vitamin B12 transporter BtuB {ECO:0000256|HAMAP-Rule:MF_01531};
DE   AltName: Full=Cobalamin receptor {ECO:0000256|HAMAP-Rule:MF_01531};
DE   AltName: Full=Outer membrane cobalamin translocator {ECO:0000256|HAMAP-Rule:MF_01531};
DE   Flags: Precursor;
GN   Name=btuB {ECO:0000256|HAMAP-Rule:MF_01531};
GN   OrderedLocusNames=AHA_0074 {ECO:0000313|EMBL:ABK39619.1};
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 /
OS   JCM 1027 / KCTC 2358 / NCIMB 9240).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK39619.1, ECO:0000313|Proteomes:UP000000756};
RN   [1] {ECO:0000313|EMBL:ABK39619.1, ECO:0000313|Proteomes:UP000000756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240
RC   {ECO:0000313|Proteomes:UP000000756};
RX   PubMed=16980456; DOI=10.1128/JB.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J.,
RA   Haft D., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M.,
RA   Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all
RT   trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Involved in the active translocation of vitamin B12
CC       (cyanocobalamin) across the outer membrane to the periplasmic
CC       space. It derives its energy for transport by interacting with the
CC       trans-periplasmic membrane protein TonB. {ECO:0000256|HAMAP-
CC       Rule:MF_01531}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01531}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01531}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family. BtuB
CC       (TC 1.B.14.3.1) subfamily. {ECO:0000256|HAMAP-Rule:MF_01531}.
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DR   EMBL; CP000462; ABK39619.1; -; Genomic_DNA.
DR   RefSeq; WP_011704111.1; NC_008570.1.
DR   RefSeq; YP_854601.1; NC_008570.1.
DR   STRING; 380703.AHA_0074; -.
DR   EnsemblBacteria; ABK39619; ABK39619; AHA_0074.
DR   GeneID; 4488611; -.
DR   KEGG; aha:AHA_0074; -.
DR   PATRIC; fig|380703.7.peg.69; -.
DR   eggNOG; ENOG4105CHI; Bacteria.
DR   eggNOG; COG4206; LUCA.
DR   HOGENOM; HOG000269547; -.
DR   KO; K16092; -.
DR   OMA; REDHDEQ; -.
DR   BioCyc; AHYD380703:G1G7B-74-MONOMER; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015420; F:cobalamin-transporting ATPase activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   HAMAP; MF_01531; BtuB; 1.
DR   InterPro; IPR010101; B12_transptr_BtuB.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
PE   3: Inferred from homology;
DR   PRODOM; A0KEE6.
DR   SWISS-2DPAGE; A0KEE6.
KW   Cell outer membrane {ECO:0000256|HAMAP-Rule:MF_01531,
KW   ECO:0000256|SAAS:SAAS01009188}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000756};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_01531};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01531,
KW   ECO:0000256|SAAS:SAAS01009224};
KW   Porin {ECO:0000256|HAMAP-Rule:MF_01531};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000756};
KW   Signal {ECO:0000256|HAMAP-Rule:MF_01531};
KW   TonB box {ECO:0000256|HAMAP-Rule:MF_01531,
KW   ECO:0000256|SAAS:SAAS01009241};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01531,
KW   ECO:0000256|SAAS:SAAS01009271};
KW   Transmembrane beta strand {ECO:0000256|HAMAP-Rule:MF_01531,
KW   ECO:0000256|SAAS:SAAS01009174};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01531}.
FT   SIGNAL        1     17       {ECO:0000256|HAMAP-Rule:MF_01531}.
FT   CHAIN        18    611       Vitamin B12 transporter BtuB.
FT                                {ECO:0000256|HAMAP-Rule:MF_01531}.
FT                                /FTId=PRO_5009006454.
FT   DOMAIN       40    144       Plug. {ECO:0000259|Pfam:PF07715}.
FT   DOMAIN      175    610       TonB_dep_Rec. {ECO:0000259|Pfam:PF00593}.
FT   COILED      499    519       {ECO:0000256|SAM:Coils}.
FT   MOTIF        25     32       TonB box. {ECO:0000256|HAMAP-Rule:
FT                                MF_01531}.
FT   MOTIF       594    611       TonB C-terminal box. {ECO:0000256|HAMAP-
FT                                Rule:MF_01531}.
SQ   SEQUENCE   611 AA;  66957 MW;  D80F497BF675C618 CRC64;
     MSKKLLAAAL LPTAAFAQTT IPVNPTLVIT ANRVEQPISS VLAPVVVIDR AEIESRQVQS
     LPALLKTLPG VQITTLGGRG HMSSLFIRGT NSNHSLVLMN GRPIAAMVAG TPDLSQIPLG
     NIERIEYIRG PRAAVYGSDA IGGVINLITK TSAKNGSETH LKGGVGSNGY GQGQLRTVQA
     LGQQTDMNMM IGYERTDGFD VVANAQQPDR DGFDSLNGQF GLSHAFNDAW SADFNAQGYD
     NQTEMDDAYQ SADQSRVQAF QYDGGLKYQS GALSSRLEAS YGENKLKSWL ESKGESSAEP
     IHTGLTRFSW INSWSGVEGL NLTGGADWQQ EQLKSDTRSY GQAFNAPDRD NTGLFVVGSY
     RWQALLWELS GRTDDNKQYG RHNTWSAASG LDLDDNHNVR LSYGTAFKAP TFLDLYYPGY
     ENPALKPEES KNLELGFSGR YTGWDWSLNL YRNQIQNLIA CQSASSTCRP DNTDAEIRGV
     EVALGLETGP LRHDLSFDYT RAEDKNDGDQ QLLRRAKQKA SWLTQVQLGP VDLSTELLYV
     GKRDDKNFSS FPAERVELGS YTLINLGASY GVTPQFTLGG RIDNLFDRDY APAYGYASAG
     TEFKLTADYR L
//

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