(data stored in ACNUC1104 zone)

SWISSPROT: NHAA1_NOCSJ

ID   NHAA1_NOCSJ             Reviewed;         434 AA.
AC   A1SDK4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   08-MAY-2019, entry version 70.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA 1 {ECO:0000255|HAMAP-Rule:MF_01844};
DE   AltName: Full=Sodium/proton antiporter NhaA 1 {ECO:0000255|HAMAP-Rule:MF_01844};
GN   Name=nhaA1 {ECO:0000255|HAMAP-Rule:MF_01844};
GN   OrderedLocusNames=Noca_0345;
OS   Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=196162;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Mattes T., Gossett J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01844}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01844}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000255|HAMAP-Rule:MF_01844}.
DR   EMBL; CP000509; ABL79889.1; -; Genomic_DNA.
DR   RefSeq; WP_011753840.1; NC_008699.1.
DR   STRING; 196162.Noca_0345; -.
DR   EnsemblBacteria; ABL79889; ABL79889; Noca_0345.
DR   KEGG; nca:Noca_0345; -.
DR   eggNOG; ENOG4105DRC; Bacteria.
DR   eggNOG; COG3004; LUCA.
DR   HOGENOM; HOG000218489; -.
DR   KO; K03313; -.
DR   OMA; LLMWVND; -.
DR   OrthoDB; 1805428at2; -.
DR   Proteomes; UP000000640; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341; PTHR30341; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
PE   3: Inferred from homology;
DR   PRODOM; A1SDK4.
DR   SWISS-2DPAGE; A1SDK4.
KW   Antiport; Cell membrane; Complete proteome; Ion transport; Membrane;
KW   Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    434       Na(+)/H(+) antiporter NhaA 1.
FT                                /FTId=PRO_0000334349.
FT   TRANSMEM     34     54       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM     73     93       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    111    131       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    141    161       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    171    191       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    194    214       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    233    253       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    278    298       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    313    333       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    346    366       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    380    400       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
SQ   SEQUENCE   434 AA;  45691 MW;  D1929CFF0CA42B7C CRC64;
     MTGRRPTRPR LFSRGSFLES SRVADILRAE TTGGLLLIAA ATVAIVWANT PWSASYADLR
     DLRVGPQAWH LDLTLGAWAA DGLLAIFFFV AGLELKREFV AGDLRDPRRA ALPVVAAMGG
     MAVPALVYVL WNLGGDGALQ GWAIPTATDI AFAVAILAVI STHLPTGLRT FLLTLAVVDD
     LLAITIIALF YTDELHLGYL AAAAVPLLVF ALLVQRRIHR GWLLIPLAAT AWVLVHESGV
     HATVAGVLLG FAVPVLRSDG QEGPGLAEHL EHLVRPLSAG LAVPVFAFFA AGVTVGGFDG
     LVDALSDPVA LGVVTGLVVG KTVGIAGSTW LLATFTRADL DDQLSWVDVV GLAMLAGIGF
     TVSLLIGELA FGSGTPRDDH VKVGVLVGSL AATALATGVL RMRNRAYRRL VEIEEQDADA
     DGVPDVYQRD ADEG
//

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