(data stored in ACNUC1104 zone)

SWISSPROT: A1SDX0_NOCSJ

ID   A1SDX0_NOCSJ            Unreviewed;       300 AA.
AC   A1SDX0;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   SubName: Full=Nicotinate-nucleotide pyrophosphorylase (Carboxylating) {ECO:0000313|EMBL:ABL80005.1};
DE            EC=2.4.2.19 {ECO:0000313|EMBL:ABL80005.1};
GN   OrderedLocusNames=Noca_0463 {ECO:0000313|EMBL:ABL80005.1};
OS   Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL80005.1, ECO:0000313|Proteomes:UP000000640};
RN   [1] {ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Mattes T., Gossett J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABL80005.1, ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RX   PubMed=21551312; DOI=10.1128/JB.05109-11;
RA   Coleman N.V., Wilson N.L., Barry K., Brettin T.S., Bruce D.C.,
RA   Copeland A., Dalin E., Detter J.C., Del Rio T.G., Goodwin L.A.,
RA   Hammon N.M., Han S., Hauser L.J., Israni S., Kim E., Kyrpides N.,
RA   Land M.L., Lapidus A., Larimer F.W., Lucas S., Pitluck S.,
RA   Richardson P., Schmutz J., Tapia R., Thompson S., Tice H.N.,
RA   Spain J.C., Gossett J.G., Mattes T.E.;
RT   "Genome Sequence of the ethene- and vinyl chloride-oxidizing
RT   actinomycete Nocardioides sp. strain JS614.";
RL   J. Bacteriol. 193:3399-3400(2011).
CC   -!- SIMILARITY: Belongs to the NadC/ModD family.
CC       {ECO:0000256|PIRNR:PIRNR006250}.
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DR   EMBL; CP000509; ABL80005.1; -; Genomic_DNA.
DR   RefSeq; WP_011753956.1; NC_008699.1.
DR   STRING; 196162.Noca_0463; -.
DR   EnsemblBacteria; ABL80005; ABL80005; Noca_0463.
DR   KEGG; nca:Noca_0463; -.
DR   eggNOG; ENOG4105D18; Bacteria.
DR   eggNOG; COG0157; LUCA.
DR   HOGENOM; HOG000224022; -.
DR   KO; K00767; -.
DR   OMA; CGGCHNH; -.
DR   OrthoDB; 1718114at2; -.
DR   BioCyc; NSP196162:GH4V-467-MONOMER; -.
DR   Proteomes; UP000000640; Chromosome.
DR   GO; GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR   CDD; cd01572; QPRTase; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   Gene3D; 3.90.1170.20; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR004393; NadC.
DR   InterPro; IPR027277; NadC/ModD.
DR   InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR   InterPro; IPR037128; Quinolinate_PRibosylTase_N_sf.
DR   InterPro; IPR002638; Quinolinate_PRibosylTrfase_C.
DR   InterPro; IPR022412; Quinolinate_PRibosylTrfase_N.
DR   PANTHER; PTHR32179; PTHR32179; 1.
DR   Pfam; PF01729; QRPTase_C; 1.
DR   Pfam; PF02749; QRPTase_N; 1.
DR   PIRSF; PIRSF006250; NadC_ModD; 1.
DR   SUPFAM; SSF51690; SSF51690; 1.
DR   TIGRFAMs; TIGR00078; nadC; 1.
PE   3: Inferred from homology;
DR   PRODOM; A1SDX0.
DR   SWISS-2DPAGE; A1SDX0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000640};
KW   Glycosyltransferase {ECO:0000256|PIRNR:PIRNR006250,
KW   ECO:0000313|EMBL:ABL80005.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000640};
KW   Transferase {ECO:0000256|PIRNR:PIRNR006250,
KW   ECO:0000313|EMBL:ABL80005.1}.
FT   DOMAIN       38    127       QRPTase_N. {ECO:0000259|Pfam:PF02749}.
FT   DOMAIN      129    293       QRPTase_C. {ECO:0000259|Pfam:PF01729}.
FT   REGION      150    152       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR006250-1}.
FT   REGION      257    259       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR006250-1}.
FT   REGION      278    280       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR006250-1}.
FT   BINDING     117    117       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR006250-1}.
FT   BINDING     174    174       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR006250-1}.
FT   BINDING     184    184       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR006250-1}.
FT   BINDING     213    213       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR006250-1}.
FT   BINDING     234    234       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR006250-1}.
SQ   SEQUENCE   300 AA;  31180 MW;  DF480658D94CA0F8 CRC64;
     MTPATPYDEE LRAAGLDPEA IRAQVARALA EDLPGGLARG DVTSVATIAA DARGTGVFAA
     REAGVVAGLG VAALVFHEVL GDAVEVTDRV PDGTRVAPGD VVMRVAGPTR GLLTAERTAL
     NYASHLSGVA TATAHWVDAL AGTRARVLDT RKTLPTFRAL QKYAVRCGGG VNHRFSLGDR
     AMVKDNHVVA AGGVVPAYDA VRRAYPDLRV EVEVTGLDEL RELLDAGCTE ILLDNMDTAT
     MAEAVRLTAG RATLEASGGL TIERAREVAE TGVDFISVGA LTHSVQVFDL GLDLSSGSEG
//

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