(data stored in ACNUC29543 zone)

SWISSPROT: DNAA_ACIBT

ID   DNAA_ACIBT              Reviewed;         465 AA.
AC   A3M0Q4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   16-JAN-2019, entry version 72.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=A1S_0001;
OS   Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 /
OS   NCDC KC755 / 5377).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Acinetobacter;
OC   Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=400667;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377;
RX   PubMed=17344419; DOI=10.1101/gad.1510307;
RA   Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N.,
RA   Gerstein M., Snyder M.;
RT   "New insights into Acinetobacter baumannii pathogenesis revealed by
RT   high-density pyrosequencing and transposon mutagenesis.";
RL   Genes Dev. 21:601-614(2007).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; CP000521; ABO10498.2; -; Genomic_DNA.
DR   SMR; A3M0Q4; -.
DR   PRIDE; A3M0Q4; -.
DR   EnsemblBacteria; ABO10498; ABO10498; A1S_0001.
DR   KEGG; acb:A1S_0001; -.
DR   HOGENOM; HOG000235659; -.
DR   KO; K02313; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
DR   PRODOM; A3M0Q4.
DR   SWISS-2DPAGE; A3M0Q4.
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding;
KW   Nucleotide-binding.
FT   CHAIN         1    465       Chromosomal replication initiator protein
FT                                DnaA.
FT                                /FTId=PRO_1000121940.
FT   NP_BIND     170    177       ATP. {ECO:0000255|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   465 AA;  52277 MW;  1674004A5431A828 CRC64;
     MLWTDCLTRL RQELSDNVFA MWIRPLVAEE VEGILRLYAP NPYWTRYIQE NHLELISILA
     EQLSEGRVRQ VEILVDSRPG SILSSSEQPA TTTAALQTAP IPQPAKVKRE PEPVANTAVS
     SKSSKKKLLN PQFTFSLFVE GRSNQMAAET CRKVLTQLGA SQHNPLFLYG PTGLGKTHLM
     QAVGNALLQA KPNARVMYMT SESFVQDFVS SLQKGKVEEF KKNCRSLDLL LVDDIHLLAG
     KEASLVEFFY TFNALLDESK QIILTSDRYP KELTELDPRL VSRFSWGLSV GVEPPDIETR
     IEILLKKAEN SGVDLPRNCA LFIAQQVVAN VRELEGALNK VVAISRFKGA PIDLDVVRES
     LKDVLAIRAR TISVENIQRV VSEYFRIPLK ELIGPKRTRI YARPRQLAMG LARELTGDSF
     PEIGMAFGGR DHSTVMHACE KVVSLREEDP IFDEDYKNLL RLLQS
//

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