(data stored in ACNUC7421 zone)

SWISSPROT: A5FTK0_ACICJ

ID   A5FTK0_ACICJ            Unreviewed;       320 AA.
AC   A5FTK0;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   05-JUL-2017, entry version 69.
DE   RecName: Full=CRISPR-associated endonuclease Cas1 {ECO:0000256|HAMAP-Rule:MF_01470};
DE            EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_01470};
GN   Name=cas1 {ECO:0000256|HAMAP-Rule:MF_01470};
GN   OrderedLocusNames=Acry_1808 {ECO:0000313|EMBL:ABQ31010.1}, Acry_3320
GN   {ECO:0000313|EMBL:ABQ28932.1};
OS   Acidiphilium cryptum (strain JF-5).
OG   Plasmid pACRY02 {ECO:0000313|EMBL:ABQ28932.1,
OG   ECO:0000313|Proteomes:UP000000245}.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Acidiphilium.
OX   NCBI_TaxID=349163 {ECO:0000313|EMBL:ABQ28932.1, ECO:0000313|Proteomes:UP000000245};
RN   [1] {ECO:0000313|EMBL:ABQ31010.1, ECO:0000313|Proteomes:UP000000245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JF-5 {ECO:0000313|EMBL:ABQ31010.1,
RC   ECO:0000313|Proteomes:UP000000245};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Magnuson T.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Acidiphilium cryptum JF-5.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABQ28932.1, ECO:0000313|Proteomes:UP000000245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JF-5 {ECO:0000313|Proteomes:UP000000245};
RC   PLASMID=JF-5 {ECO:0000313|EMBL:ABQ28932.1}, pACRY02
RC   {ECO:0000313|EMBL:ABQ28932.1}, and Plasmid pACRY02
RC   {ECO:0000313|Proteomes:UP000000245};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Magnuson T.,
RA   Richardson P.;
RT   "Complete sequence of plasmid2 pACRY02 of Acidiphilium cryptum JF-5.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short
CC       palindromic repeat), is an adaptive immune system that provides
CC       protection against mobile genetic elements (viruses, transposable
CC       elements and conjugative plasmids). CRISPR clusters contain
CC       spacers, sequences complementary to antecedent mobile elements,
CC       and target invading nucleic acids. CRISPR clusters are transcribed
CC       and processed into CRISPR RNA (crRNA). Acts as a dsDNA
CC       endonuclease. Involved in the integration of spacer DNA into the
CC       CRISPR cassette. {ECO:0000256|HAMAP-Rule:MF_01470}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01470};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01470};
CC   -!- SUBUNIT: Homodimer, forms a heterotetramer with a Cas2 homodimer.
CC       {ECO:0000256|HAMAP-Rule:MF_01470}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated endonuclease Cas1
CC       family. {ECO:0000256|HAMAP-Rule:MF_01470}.
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DR   EMBL; CP000690; ABQ28932.1; -; Genomic_DNA.
DR   EMBL; CP000697; ABQ31010.1; -; Genomic_DNA.
DR   RefSeq; WP_007424557.1; NC_009484.1.
DR   ProteinModelPortal; A5FTK0; -.
DR   STRING; 349163.Acry_1808; -.
DR   EnsemblBacteria; ABQ28932; ABQ28932; Acry_3320.
DR   EnsemblBacteria; ABQ31010; ABQ31010; Acry_1808.
DR   KEGG; acr:Acry_1808; -.
DR   KEGG; acr:Acry_3320; -.
DR   eggNOG; ENOG4105TZK; Bacteria.
DR   eggNOG; COG1518; LUCA.
DR   HOGENOM; HOG000015862; -.
DR   KO; K15342; -.
DR   OMA; IWVGEAG; -.
DR   OrthoDB; POG091H0OKM; -.
DR   Proteomes; UP000000245; Chromosome.
DR   Proteomes; UP000000245; Plasmid pACRY02.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004520; F:endodeoxyribonuclease activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-HAMAP.
DR   GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:UniProtKB-HAMAP.
DR   CDD; cd09719; Cas1_I-E; 1.
DR   HAMAP; MF_01470; Cas1; 1.
DR   InterPro; IPR033641; Cas1_I-E.
DR   InterPro; IPR002729; CRISPR-assoc_Cas1.
DR   InterPro; IPR019851; CRISPR-assoc_Cas1_ECOLI.
DR   Pfam; PF01867; Cas_Cas1; 1.
DR   TIGRFAMs; TIGR00287; cas1; 1.
DR   TIGRFAMs; TIGR03638; cas1_ECOLI; 1.
PE   3: Inferred from homology;
DR   PRODOM; A5FTK0.
DR   SWISS-2DPAGE; A5FTK0.
KW   Antiviral defense {ECO:0000256|HAMAP-Rule:MF_01470};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000245};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01470};
KW   Endonuclease {ECO:0000256|HAMAP-Rule:MF_01470};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01470};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_01470};
KW   Manganese {ECO:0000256|HAMAP-Rule:MF_01470};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01470};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_01470};
KW   Plasmid {ECO:0000313|EMBL:ABQ28932.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000245}.
FT   METAL       146    146       Manganese or magnesium.
FT                                {ECO:0000256|HAMAP-Rule:MF_01470}.
FT   METAL       213    213       Manganese or magnesium.
FT                                {ECO:0000256|HAMAP-Rule:MF_01470}.
FT   METAL       226    226       Manganese or magnesium.
FT                                {ECO:0000256|HAMAP-Rule:MF_01470}.
SQ   SEQUENCE   320 AA;  34528 MW;  D8A44154D663C7F7 CRC64;
     MSDQAPGLPP PRPIPIRERS SILFLERGQL DVIDGSFVVV DQRGIRTVIP VGGITCLMLE
     PGTRVSHAAV CLAARAGTLL IWVGEAGVRL YAAGQPGGAR SDRLLYQARL ALDDEARLRV
     VRRMYSIRFQ EEPPQRRSVD QLRGIEGVRV RELYKLMAQR HGVSWAGRRY DPQNWGGADL
     VNRCLSAATA ALYGISEAAI LAAGYAPAIG FLHSGKPQSF VYDIADLFKF ETVVPEAFKV
     VAAVQSGRGQ IDGMAIGEPV GAVRRRCRDA FRRTNVLARI IPAIEDVLAA GGLAVPEAPE
     EAMPVAIPPP EPTGDAGHRG
//

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