(data stored in ACNUC7421 zone)

SWISSPROT: TSAC_SHESH

ID   TSAC_SHESH              Reviewed;         185 AA.
AC   A8FP81;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   07-JUN-2017, entry version 59.
DE   RecName: Full=Threonylcarbamoyl-AMP synthase {ECO:0000255|HAMAP-Rule:MF_01852};
DE            Short=TC-AMP synthase {ECO:0000255|HAMAP-Rule:MF_01852};
DE            EC=2.7.7.87 {ECO:0000255|HAMAP-Rule:MF_01852};
DE   AltName: Full=L-threonylcarbamoyladenylate synthase {ECO:0000255|HAMAP-Rule:MF_01852};
DE   AltName: Full=t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000255|HAMAP-Rule:MF_01852};
DE   AltName: Full=tRNA threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000255|HAMAP-Rule:MF_01852};
GN   Name=tsaC {ECO:0000255|HAMAP-Rule:MF_01852}; Synonyms=rimN;
GN   OrderedLocusNames=Ssed_0041;
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the formation of a threonylcarbamoyl group
CC       on adenosine at position 37 (t(6)A37) in tRNAs that read codons
CC       beginning with adenine. Catalyzes the conversion of L-threonine,
CC       HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as
CC       the acyladenylate intermediate, with the release of diphosphate.
CC       {ECO:0000255|HAMAP-Rule:MF_01852}.
CC   -!- CATALYTIC ACTIVITY: L-threonine + ATP + HCO(3)(-) = L-
CC       threonylcarbamoyladenylate + diphosphate + H(2)O.
CC       {ECO:0000255|HAMAP-Rule:MF_01852}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01852}.
CC   -!- SIMILARITY: Belongs to the SUA5 family. TsaC subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01852}.
DR   EMBL; CP000821; ABV34654.1; -; Genomic_DNA.
DR   RefSeq; WP_012004180.1; NC_009831.1.
DR   ProteinModelPortal; A8FP81; -.
DR   STRING; 425104.Ssed_0041; -.
DR   EnsemblBacteria; ABV34654; ABV34654; Ssed_0041.
DR   KEGG; sse:Ssed_0041; -.
DR   eggNOG; ENOG4105EK0; Bacteria.
DR   eggNOG; COG0009; LUCA.
DR   HOGENOM; HOG000076163; -.
DR   KO; K07566; -.
DR   OMA; FGLGCNP; -.
DR   OrthoDB; POG091H00HZ; -.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR   GO; GO:0061710; F:L-threonylcarbamoyladenylate synthase; IEA:UniProtKB-EC.
DR   GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IEA:InterPro.
DR   Gene3D; 3.90.870.10; -; 1.
DR   HAMAP; MF_01852; TsaC; 1.
DR   InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom.
DR   InterPro; IPR023535; TC-AMP_synthase.
DR   InterPro; IPR006070; YrdC-like_dom.
DR   Pfam; PF01300; Sua5_yciO_yrdC; 1.
DR   SUPFAM; SSF55821; SSF55821; 1.
DR   TIGRFAMs; TIGR00057; TIGR00057; 1.
DR   PROSITE; PS51163; YRDC; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8FP81.
DR   SWISS-2DPAGE; A8FP81.
KW   ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding;
KW   Nucleotidyltransferase; Transferase; tRNA processing.
FT   CHAIN         1    185       Threonylcarbamoyl-AMP synthase.
FT                                /FTId=PRO_0000352985.
FT   DOMAIN        3    185       YrdC-like. {ECO:0000255|HAMAP-
FT                                Rule:MF_01852}.
SQ   SEQUENCE   185 AA;  20088 MW;  AF3ACBC492CD6722 CRC64;
     MLEQAPDEVQ EIIEQGGVVA YPTEAVYGLG CDPDNDEAIT RLLALKKRPW QKGLILVASD
     YQQLLPYIDE SRLTNEQLNK VFVKWPGPFT FIMPIKPGLS NLLCGSFNSL AVRVSSHPTI
     QAICQRLGKP LVSTSANHAG EPPAMSCEEI IAKFDGEIDA LISGSLGAER KPSTIVDAIS
     GKVLR
//

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