(data stored in ACNUC7421 zone)

SWISSPROT: A8FPE6_SHESH

ID   A8FPE6_SHESH            Unreviewed;       289 AA.
AC   A8FPE6;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   30-AUG-2017, entry version 56.
DE   RecName: Full=dTDP-4-dehydrorhamnose reductase {ECO:0000256|RuleBase:RU364082};
DE            EC=1.1.1.133 {ECO:0000256|RuleBase:RU364082};
GN   OrderedLocusNames=Ssed_0106 {ECO:0000313|EMBL:ABV34719.1};
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104 {ECO:0000313|EMBL:ABV34719.1, ECO:0000313|Proteomes:UP000002015};
RN   [1] {ECO:0000313|EMBL:ABV34719.1, ECO:0000313|Proteomes:UP000002015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3 {ECO:0000313|EMBL:ABV34719.1,
RC   ECO:0000313|Proteomes:UP000002015};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-
CC       hexulose to yield dTDP-L-rhamnose.
CC       {ECO:0000256|RuleBase:RU364082}.
CC   -!- CATALYTIC ACTIVITY: dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-
CC       dehydro-beta-L-rhamnose + NADPH. {ECO:0000256|RuleBase:RU364082}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU364082};
CC       Note=Binds 1 Mg(2+) ion per monomer.
CC       {ECO:0000256|RuleBase:RU364082};
CC   -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC       {ECO:0000256|RuleBase:RU364082}.
CC   -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose reductase
CC       family. {ECO:0000256|RuleBase:RU364082}.
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DR   EMBL; CP000821; ABV34719.1; -; Genomic_DNA.
DR   RefSeq; WP_012004245.1; NC_009831.1.
DR   ProteinModelPortal; A8FPE6; -.
DR   STRING; 425104.Ssed_0106; -.
DR   EnsemblBacteria; ABV34719; ABV34719; Ssed_0106.
DR   KEGG; sse:Ssed_0106; -.
DR   eggNOG; ENOG4105DBZ; Bacteria.
DR   eggNOG; COG1091; LUCA.
DR   HOGENOM; HOG000227712; -.
DR   KO; K00067; -.
DR   OMA; AYRINAI; -.
DR   OrthoDB; POG091H07IL; -.
DR   BioCyc; SSED425104:GH7Q-109-MONOMER; -.
DR   UniPathway; UPA00124; -.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR005913; dTDP_dehydrorham_reduct.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR029903; RmlD-like-bd.
DR   PANTHER; PTHR10491; PTHR10491; 1.
DR   Pfam; PF04321; RmlD_sub_bind; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01214; rmlD; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8FPE6.
DR   SWISS-2DPAGE; A8FPE6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002015};
KW   NADP {ECO:0000256|RuleBase:RU364082};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU364082,
KW   ECO:0000313|EMBL:ABV34719.1}.
FT   DOMAIN        7    288       RmlD_sub_bind. {ECO:0000259|Pfam:
FT                                PF04321}.
SQ   SEQUENCE   289 AA;  31942 MW;  BDCA6E7719F1DE72 CRC64;
     MTNSRLKVLI LGKSGQLAQA LIANKPTPIE CVALGHLDIN LAVTGEIESA ITTNRADIII
     NTAAYTQVDL AESEPSLAFE INALAVENIA KAARNTNVHL IHLSTDYVFD GKQSTPYTIF
     DTPHPINIYG ASKLTGEKAL RQCMPVGSTT VRTSSVYSQY GNNFVKTMLR LMREKSEIKV
     ISDQISSPTS AKELARFLWM LTEQESLSPL YHWCDSGKTS WYQFAVTIQQ LALKYGKLEK
     AISIIPISSQ EYGAAALRPP FSQLDIGQSQ ALLHSKPWQE NLESLIKRL
//

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