(data stored in ACNUC7421 zone)

SWISSPROT: CYOE_SHESH

ID   CYOE_SHESH              Reviewed;         304 AA.
AC   A8FPN0;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   07-JUN-2017, entry version 65.
DE   RecName: Full=Protoheme IX farnesyltransferase {ECO:0000255|HAMAP-Rule:MF_00154};
DE            EC=2.5.1.- {ECO:0000255|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme B farnesyltransferase {ECO:0000255|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme O synthase {ECO:0000255|HAMAP-Rule:MF_00154};
GN   Name=cyoE {ECO:0000255|HAMAP-Rule:MF_00154};
GN   OrderedLocusNames=Ssed_0190;
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC       biosynthesis; heme O from protoheme: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00154}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       Protoheme IX farnesyltransferase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
DR   EMBL; CP000821; ABV34803.1; -; Genomic_DNA.
DR   RefSeq; WP_012004329.1; NC_009831.1.
DR   STRING; 425104.Ssed_0190; -.
DR   EnsemblBacteria; ABV34803; ABV34803; Ssed_0190.
DR   KEGG; sse:Ssed_0190; -.
DR   eggNOG; ENOG4105F1R; Bacteria.
DR   eggNOG; COG0109; LUCA.
DR   HOGENOM; HOG000237291; -.
DR   KO; K02301; -.
DR   OMA; HRKEEYA; -.
DR   OrthoDB; POG091H05F2; -.
DR   UniPathway; UPA00834; UER00712.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:InterPro.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd13957; PT_UbiA_Cox10; 1.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8FPN0.
DR   SWISS-2DPAGE; A8FPN0.
KW   Cell inner membrane; Cell membrane; Complete proteome;
KW   Heme biosynthesis; Membrane; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    304       Protoheme IX farnesyltransferase.
FT                                /FTId=PRO_0000346016.
FT   TRANSMEM     32     52       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM     54     74       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    104    124       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    126    146       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    154    174       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    180    200       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    226    246       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    247    267       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    284    304       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
SQ   SEQUENCE   304 AA;  33247 MW;  01F69E9059877D68 CRC64;
     MAKQLSIPSA TSGSKSHSLA WRPYYEMTKP KVVALMLLTV LVGMCLAVPG SVPLQPLVIG
     MIGIGMMAGA AAAFNHLIDR KIDGLMARTY NRPLPKGRVS IPKALTFAIS LAALGFVLLY
     TLVNELTAWL TFASLIGYAL VYTAYLKRAT PQNIVVGGLA GAMPPLLGWT SVTGEFHGHA
     LLLVIIIFAW TPPHFWALAI HRKAEYAKVD IPMLPVTHGT EFTKTCILLY TVLLAIACLL
     PVLVGMCGPV YLVGSTLLSC GFIYKAWELK FDDKPGLAMQ VFRFSIYHLM LLFLVLLVDH
     YLWV
//

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