(data stored in ACNUC7421 zone)

SWISSPROT: A8FPR5_SHESH

ID   A8FPR5_SHESH            Unreviewed;       260 AA.
AC   A8FPR5;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   07-JUN-2017, entry version 62.
DE   RecName: Full=Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase {ECO:0000256|HAMAP-Rule:MF_01660};
DE            Short=SHCHC synthase {ECO:0000256|HAMAP-Rule:MF_01660};
DE            EC=4.2.99.20 {ECO:0000256|HAMAP-Rule:MF_01660};
GN   Name=menH {ECO:0000256|HAMAP-Rule:MF_01660};
GN   OrderedLocusNames=Ssed_0225 {ECO:0000313|EMBL:ABV34838.1};
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104 {ECO:0000313|EMBL:ABV34838.1, ECO:0000313|Proteomes:UP000002015};
RN   [1] {ECO:0000313|EMBL:ABV34838.1, ECO:0000313|Proteomes:UP000002015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3 {ECO:0000313|EMBL:ABV34838.1,
RC   ECO:0000313|Proteomes:UP000002015};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes a proton abstraction reaction that results in
CC       2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-
CC       hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of
CC       2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
CC       {ECO:0000256|HAMAP-Rule:MF_01660, ECO:0000256|SAAS:SAAS00195260}.
CC   -!- CATALYTIC ACTIVITY: 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-
CC       ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-
CC       diene-1-carboxylate + pyruvate. {ECO:0000256|HAMAP-Rule:MF_01660,
CC       ECO:0000256|SAAS:SAAS00346598}.
CC   -!- PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate
CC       biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step
CC       3/7. {ECO:0000256|HAMAP-Rule:MF_01660,
CC       ECO:0000256|SAAS:SAAS00346614}.
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_01660, ECO:0000256|SAAS:SAAS00346607}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_01660,
CC       ECO:0000256|SAAS:SAAS00346595}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. MenH family.
CC       {ECO:0000256|HAMAP-Rule:MF_01660, ECO:0000256|SAAS:SAAS00541818}.
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DR   EMBL; CP000821; ABV34838.1; -; Genomic_DNA.
DR   RefSeq; WP_012004364.1; NC_009831.1.
DR   ProteinModelPortal; A8FPR5; -.
DR   STRING; 425104.Ssed_0225; -.
DR   ESTHER; shesh-a8fpr5; MenH_SHCHC.
DR   EnsemblBacteria; ABV34838; ABV34838; Ssed_0225.
DR   KEGG; sse:Ssed_0225; -.
DR   eggNOG; ENOG4107J5P; Bacteria.
DR   eggNOG; COG0596; LUCA.
DR   HOGENOM; HOG000028072; -.
DR   KO; K08680; -.
DR   OMA; LNDWYQQ; -.
DR   OrthoDB; POG091H05R7; -.
DR   UniPathway; UPA00079; -.
DR   UniPathway; UPA01057; UER00900.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0070205; F:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   HAMAP; MF_01660; MenH; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR022485; SHCHC_synthase_MenH.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   TIGRFAMs; TIGR03695; menH_SHCHC; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8FPR5.
DR   SWISS-2DPAGE; A8FPR5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002015};
KW   Hydrolase {ECO:0000313|EMBL:ABV34838.1};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_01660,
KW   ECO:0000256|SAAS:SAAS00424766};
KW   Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_01660,
KW   ECO:0000256|SAAS:SAAS00424765}.
FT   DOMAIN       13    144       AB hydrolase-1 (Alpha/Beta hydrolase fold
FT                                1). {ECO:0000259|Pfam:PF00561}.
SQ   SEQUENCE   260 AA;  28809 MW;  37278909B04CBD3B CRC64;
     MLALSCHGDS RKPALVMLHG FLGSKNDWDT LISDLLPHFY CICIDLPGHG QSPVLAPGSS
     AFERVADAIQ TTLNSLSIER YHLLGYSLGG RIALHVAQAY PDNLLSLSLE SSHPGLQTLA
     ERQVRARNDH SWSEKLSSVP IESFLSQWYQ QGVFAELTES KRQALILKRS NNSSEALLTV
     FESTSLAKQE DLWQLPGQLQ LPCHYFVGKD DSKFSALASR WASLADIQVH EIADAGHNVH
     LASPTLFCRQ LIKHLIEDAQ
//

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