(data stored in ACNUC7421 zone)

SWISSPROT: MURC_SHESH

ID   MURC_SHESH              Reviewed;         489 AA.
AC   A8FQA1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   07-JUN-2017, entry version 71.
DE   RecName: Full=UDP-N-acetylmuramate--L-alanine ligase {ECO:0000255|HAMAP-Rule:MF_00046};
DE            EC=6.3.2.8 {ECO:0000255|HAMAP-Rule:MF_00046};
DE   AltName: Full=UDP-N-acetylmuramoyl-L-alanine synthetase {ECO:0000255|HAMAP-Rule:MF_00046};
GN   Name=murC {ECO:0000255|HAMAP-Rule:MF_00046};
GN   OrderedLocusNames=Ssed_0411;
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cell wall formation. {ECO:0000255|HAMAP-Rule:MF_00046}.
CC   -!- CATALYTIC ACTIVITY: ATP + UDP-N-acetyl-alpha-D-muramate + L-
CC       alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-
CC       alanine. {ECO:0000255|HAMAP-Rule:MF_00046}.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00046}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00046}.
CC   -!- SIMILARITY: Belongs to the MurCDEF family. {ECO:0000255|HAMAP-
CC       Rule:MF_00046}.
DR   EMBL; CP000821; ABV35024.1; -; Genomic_DNA.
DR   RefSeq; WP_012140761.1; NC_009831.1.
DR   ProteinModelPortal; A8FQA1; -.
DR   SMR; A8FQA1; -.
DR   STRING; 425104.Ssed_0411; -.
DR   EnsemblBacteria; ABV35024; ABV35024; Ssed_0411.
DR   KEGG; sse:Ssed_0411; -.
DR   eggNOG; ENOG4105DFU; Bacteria.
DR   eggNOG; COG0773; LUCA.
DR   HOGENOM; HOG000256031; -.
DR   KO; K01924; -.
DR   OMA; LTMGAGD; -.
DR   OrthoDB; POG091H02MF; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008763; F:UDP-N-acetylmuramate-L-alanine ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1190.10; -; 1.
DR   HAMAP; MF_00046; MurC; 1.
DR   InterPro; IPR004101; Mur_ligase_C.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   InterPro; IPR000713; Mur_ligase_N.
DR   InterPro; IPR005758; UDP-N-AcMur_Ala_ligase_murC.
DR   Pfam; PF01225; Mur_ligase; 1.
DR   Pfam; PF02875; Mur_ligase_C; 1.
DR   Pfam; PF08245; Mur_ligase_M; 1.
DR   SUPFAM; SSF53244; SSF53244; 1.
DR   SUPFAM; SSF53623; SSF53623; 1.
DR   TIGRFAMs; TIGR01082; murC; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8FQA1.
DR   SWISS-2DPAGE; A8FQA1.
KW   ATP-binding; Cell cycle; Cell division; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;
KW   Ligase; Nucleotide-binding; Peptidoglycan synthesis.
FT   CHAIN         1    489       UDP-N-acetylmuramate--L-alanine ligase.
FT                                /FTId=PRO_1000074756.
FT   NP_BIND     128    134       ATP. {ECO:0000255|HAMAP-Rule:MF_00046}.
SQ   SEQUENCE   489 AA;  53093 MW;  7BDB2A8951008665 CRC64;
     MSKNQEKYSQ LRSIIPEMRR VKHIYFVGIG GAGMGGIAEV LVNEGYKLSG SDIAENAVTQ
     RLASLGAKIH IGHREEQVHG ADVVVVSTAI SADNPELLEA QALRIPVVQR AEMLAELMRY
     RHGVAVAGTH GKTTTTSLIA SVYGQAERDP TFVIGGLLNS AGTNARLGHS RYLIAEADES
     DASFLHLQPM VSVVTNIEAD HMDTYEGDFE KLKSTFIDFL HNLPFYGVAV MCIDDPVVRE
     LLPKVGRKIV TYGFSEDADV QALNFVQEAY LSRFTLRRAG VEDMEVVVNL PGQHNVLNAL
     AAIAVATEDE IDDAAIIQAL ADFQGIGRRF EQLGCFDTNK GEMVLVDDYG HHPSEVAATI
     KAAKAGWPEK RLVMVYQPHR YSRTRDLYDD FVEVLSQVDC LLLLDVYAAG ESPVPGADSR
     ALCRSIRQRG QLDPIFVSDS EQLLSLLPDV LQAGDLVLTQ GAGNIGAIAK QLSLSSLGFD
     LAASGTGKE
//

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