(data stored in ACNUC7421 zone)

SWISSPROT: DCUP_SHESH

ID   DCUP_SHESH              Reviewed;         354 AA.
AC   A8FQD0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   07-JUN-2017, entry version 66.
DE   RecName: Full=Uroporphyrinogen decarboxylase {ECO:0000255|HAMAP-Rule:MF_00218};
DE            Short=UPD {ECO:0000255|HAMAP-Rule:MF_00218};
DE            Short=URO-D {ECO:0000255|HAMAP-Rule:MF_00218};
DE            EC=4.1.1.37 {ECO:0000255|HAMAP-Rule:MF_00218};
GN   Name=hemE {ECO:0000255|HAMAP-Rule:MF_00218};
GN   OrderedLocusNames=Ssed_0440;
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the decarboxylation of four acetate groups of
CC       uroporphyrinogen-III to yield coproporphyrinogen-III.
CC       {ECO:0000255|HAMAP-Rule:MF_00218}.
CC   -!- CATALYTIC ACTIVITY: Uroporphyrinogen III = coproporphyrinogen + 4
CC       CO(2). {ECO:0000255|HAMAP-Rule:MF_00218}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-
CC       IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate:
CC       step 4/4. {ECO:0000255|HAMAP-Rule:MF_00218}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00218}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00218}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00218}.
DR   EMBL; CP000821; ABV35053.1; -; Genomic_DNA.
DR   RefSeq; WP_012140790.1; NC_009831.1.
DR   ProteinModelPortal; A8FQD0; -.
DR   SMR; A8FQD0; -.
DR   STRING; 425104.Ssed_0440; -.
DR   EnsemblBacteria; ABV35053; ABV35053; Ssed_0440.
DR   KEGG; sse:Ssed_0440; -.
DR   eggNOG; ENOG4105CFZ; Bacteria.
DR   eggNOG; COG0407; LUCA.
DR   HOGENOM; HOG000253896; -.
DR   KO; K01599; -.
DR   OMA; SWAGQLS; -.
DR   OrthoDB; POG091H040E; -.
DR   UniPathway; UPA00251; UER00321.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00717; URO-D; 1.
DR   HAMAP; MF_00218; URO_D; 1.
DR   InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR   InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR   Pfam; PF01208; URO-D; 1.
DR   TIGRFAMs; TIGR01464; hemE; 1.
DR   PROSITE; PS00906; UROD_1; 1.
DR   PROSITE; PS00907; UROD_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8FQD0.
DR   SWISS-2DPAGE; A8FQD0.
KW   Complete proteome; Cytoplasm; Decarboxylase; Lyase;
KW   Porphyrin biosynthesis.
FT   CHAIN         1    354       Uroporphyrinogen decarboxylase.
FT                                /FTId=PRO_1000078090.
FT   REGION       27     31       Substrate binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00218}.
FT   BINDING      77     77       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_00218}.
FT   BINDING     154    154       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_00218}.
FT   BINDING     209    209       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_00218}.
FT   BINDING     327    327       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_00218}.
FT   SITE         77     77       Transition state stabilizer.
FT                                {ECO:0000255|HAMAP-Rule:MF_00218}.
SQ   SEQUENCE   354 AA;  39528 MW;  ABC5E151A6B8F7CE CRC64;
     MAELKNDRYL RALLKQPVDR TPVWMMRQAG RYLPEYKATR AEAGDFMSLC KNQDLACEVT
     LQPLRRYDLD AAILFSDILT VPDAMGLGLY FETGEGPRFQ RPTDTIDSIK KLCIPDPEDE
     LGYVMRAVST IRRELKGEVP LIGFSGSPWT LATYMVEGGS SKTFEKIKKM AYEEPATLHL
     LLDKLADSVI LYLNAQVANG AQSLMIFDSW GGALSHHAYR EFSLRYMQKI VDGLTRHADG
     RQVPVTLFTK GGGLWLESMA ETGCDALGLD WTVDIGDARR RVGHKVALQG NMDPSVLYAS
     PERIHQEVDQ ILSSYGEGTG HVFNLGHGIH QHVDPEHAGS FINSVHELSA QYHK
//

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