(data stored in ACNUC7421 zone)

SWISSPROT: UBIA_SHESH

ID   UBIA_SHESH              Reviewed;         286 AA.
AC   A8FQF8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   07-JUN-2017, entry version 66.
DE   RecName: Full=4-hydroxybenzoate octaprenyltransferase {ECO:0000255|HAMAP-Rule:MF_01635};
DE            EC=2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01635};
DE   AltName: Full=4-HB polyprenyltransferase {ECO:0000255|HAMAP-Rule:MF_01635};
GN   Name=ubiA {ECO:0000255|HAMAP-Rule:MF_01635};
GN   OrderedLocusNames=Ssed_0468;
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB)
CC       with an all-trans polyprenyl group. Mediates the second step in
CC       the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis,
CC       which is the condensation of the polyisoprenoid side chain with
CC       PHB, generating the first membrane-bound Q intermediate 3-
CC       octaprenyl-4-hydroxybenzoate. {ECO:0000255|HAMAP-Rule:MF_01635}.
CC   -!- CATALYTIC ACTIVITY: 4-hydroxybenzoate + farnesylfarnesylgeraniol =
CC       3-octaprenyl-4-hydroxybenzoate. {ECO:0000255|HAMAP-Rule:MF_01635}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01635};
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01635}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01635}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01635}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01635}.
DR   EMBL; CP000821; ABV35081.1; -; Genomic_DNA.
DR   RefSeq; WP_012140818.1; NC_009831.1.
DR   STRING; 425104.Ssed_0468; -.
DR   EnsemblBacteria; ABV35081; ABV35081; Ssed_0468.
DR   KEGG; sse:Ssed_0468; -.
DR   eggNOG; ENOG4105C4G; Bacteria.
DR   eggNOG; COG0382; LUCA.
DR   HOGENOM; HOG000003696; -.
DR   KO; K03179; -.
DR   OMA; WTLGFDT; -.
DR   OrthoDB; POG091H03R0; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004659; F:prenyltransferase activity; IEA:InterPro.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01635; UbiA; 1.
DR   InterPro; IPR031103; HB_octoprenylTrfase.
DR   InterPro; IPR006370; HB_polyprenyltransferase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8FQF8.
DR   SWISS-2DPAGE; A8FQF8.
KW   Cell inner membrane; Cell membrane; Complete proteome; Magnesium;
KW   Membrane; Transferase; Transmembrane; Transmembrane helix;
KW   Ubiquinone biosynthesis.
FT   CHAIN         1    286       4-hydroxybenzoate octaprenyltransferase.
FT                                /FTId=PRO_1000088187.
FT   TRANSMEM     20     40       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM     43     63       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM     95    115       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM    142    162       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM    167    187       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM    210    230       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
FT   TRANSMEM    234    254       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01635}.
SQ   SEQUENCE   286 AA;  32002 MW;  DB511ED27AC61DF2 CRC64;
     MNLRDKLDVY LRLARMDRPI GTLLLLWPCL MALLLAAGGM PDLKVLTIFI FGVVVMRACG
     CIINDYADRD LDAHVDRTKS RPLASGEVTG REALILFAVM GLFAFGLVLM LNPLVVKLSV
     VGIILTIIYP FTKRFTNMPQ MFLGVVWSWS IPMAYAAQTG EVPAEAWWLF AANWCWTVAY
     DTMYAMVDRE DDLKVGIKST AILFGKYDRQ IIGLFQLAAL ACFITAGWAA DRGLVYGLGI
     ITFVGFSMYQ QKLIHERERA PCFKAFLNNN WAGLSLFIAL GVDYLI
//

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