(data stored in ACNUC7421 zone)

SWISSPROT: A8FQM3_SHESH

ID   A8FQM3_SHESH            Unreviewed;       742 AA.
AC   A8FQM3;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   07-JUN-2017, entry version 72.
DE   RecName: Full=Primosomal protein N' {ECO:0000256|HAMAP-Rule:MF_00983};
DE            EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00983};
DE   AltName: Full=ATP-dependent helicase PriA {ECO:0000256|HAMAP-Rule:MF_00983};
GN   Name=priA {ECO:0000256|HAMAP-Rule:MF_00983};
GN   OrderedLocusNames=Ssed_0534 {ECO:0000313|EMBL:ABV35146.1};
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104 {ECO:0000313|EMBL:ABV35146.1, ECO:0000313|Proteomes:UP000002015};
RN   [1] {ECO:0000313|EMBL:ABV35146.1, ECO:0000313|Proteomes:UP000002015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3 {ECO:0000313|EMBL:ABV35146.1,
RC   ECO:0000313|Proteomes:UP000002015};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the restart of stalled replication forks.
CC       Recognizes and binds the arrested nascent DNA chain at stalled
CC       replication forks. It can open the DNA duplex, via its helicase
CC       activity, and promote assembly of the primosome and loading of the
CC       major replicative helicase DnaB onto DNA. {ECO:0000256|HAMAP-
CC       Rule:MF_00983}.
CC   -!- SUBUNIT: Component of the primosome. {ECO:0000256|HAMAP-
CC       Rule:MF_00983}.
CC   -!- SIMILARITY: Belongs to the helicase family. PriA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00983}.
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DR   EMBL; CP000821; ABV35146.1; -; Genomic_DNA.
DR   ProteinModelPortal; A8FQM3; -.
DR   STRING; 425104.Ssed_0534; -.
DR   EnsemblBacteria; ABV35146; ABV35146; Ssed_0534.
DR   KEGG; sse:Ssed_0534; -.
DR   eggNOG; ENOG4105C25; Bacteria.
DR   eggNOG; COG1198; LUCA.
DR   HOGENOM; HOG000037413; -.
DR   KO; K04066; -.
DR   OMA; FQNRRGY; -.
DR   OrthoDB; POG091H02CW; -.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00983; PriA; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005259; PriA.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   TIGRFAMs; TIGR00595; priA; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8FQM3.
DR   SWISS-2DPAGE; A8FQM3.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00983};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002015};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00983};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00983};
KW   Helicase {ECO:0000256|HAMAP-Rule:MF_00983};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00983};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00983};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00983};
KW   Primosome {ECO:0000256|HAMAP-Rule:MF_00983};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00983};
KW   Zinc-finger {ECO:0000256|HAMAP-Rule:MF_00983}.
FT   DOMAIN      224    390       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      484    643       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   ZN_FING     449    461       C4-type. {ECO:0000256|HAMAP-Rule:
FT                                MF_00983}.
FT   ZN_FING     476    492       C4-type. {ECO:0000256|HAMAP-Rule:
FT                                MF_00983}.
SQ   SEQUENCE   742 AA;  82461 MW;  16B92F9CA59B1ECE CRC64;
     MLVSIDQSCH PMPLFVEVAL PVPMRQAFSY KVPDSISTLP KKGMRVKVPF GRQQLIGLVT
     GISDTCNLAP QQIKSIFELL DDEPLLPDSL YKLTAWAARY YFCSLGQMLS QAIPVALRKG
     AEISSNTTTF WHLTQSGRSA SLDTLKRAPA QKKVMEHLLK GELTQDEISS LALSKSALKA
     LNERAWITQD ERVNSIDLSW REKLELDEDP LTLNPEQAIA VATLNQQTGY HCTLLEGITG
     SGKTEVYLAL LESVLSKGKQ ALILVPEIGL TPQTISRFKS RFKVQVAVIH SGLTDNQRLA
     AWQQAKTGEA AIIIGTRSAL FTPMAFPGVI ILDEEHDSSF KQQEGVGYHA RDLAVMRGHL
     EKIPVLLGTA TPSLESLQNA LSGRYKHLEL GQRAGNAEKV RQGIIDISNQ PLNTGLSHAL
     LNEMRIHLDA GNQVLLFLNR RGFAPALLCH ECGHLHECDR CDAFFTVHQS LGEIRCHHCG
     NHYAIPKQCH NCGSTMLMGQ GVGTEQLANI LEKEFPKYPV VRIDRDTTSR KGALEAHLNA
     IHKGEYKILV GTQMLAKGHH FPDVTLVGLL DVDGALFSAD FRAPERFGQL YTQVSGRAGR
     ARKPGTVLMQ THQADNPVLR ELMHKGYGEF ARGQLNERKQ ALLPPAWHML LIRAEAHQAL
     DADNFLSQVA ELLPQNEESE VIGPMPAPMD KKAGKYRRHL IFQTKSRNQL QHAFEHALPQ
     IESLPLAKRC RWSLDRDPQD LL
//

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