(data stored in ACNUC7421 zone)

SWISSPROT: A8LCI0_FRASN

ID   A8LCI0_FRASN            Unreviewed;       313 AA.
AC   A8LCI0;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   08-MAY-2019, entry version 57.
DE   RecName: Full=Futalosine hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
DE            Short=FL hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
DE            EC=3.2.2.26 {ECO:0000256|HAMAP-Rule:MF_00991};
DE   AltName: Full=Futalosine nucleosidase {ECO:0000256|HAMAP-Rule:MF_00991};
DE   AltName: Full=Menaquinone biosynthetic enzyme MqnB {ECO:0000256|HAMAP-Rule:MF_00991};
GN   Name=mqnB {ECO:0000256|HAMAP-Rule:MF_00991};
GN   OrderedLocusNames=Franean1_0152 {ECO:0000313|EMBL:ABW09619.1};
OS   Frankia sp. (strain EAN1pec).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW09619.1, ECO:0000313|Proteomes:UP000001313};
RN   [1] {ECO:0000313|Proteomes:UP000001313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EAN1pec {ECO:0000313|Proteomes:UP000001313};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Catalyzes the hydrolysis of futalosine (FL) to
CC       dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the
CC       biosynthesis of menaquinone (MK, vitamin K2). {ECO:0000256|HAMAP-
CC       Rule:MF_00991}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=futalosine + H2O = dehypoxanthine futalosine +
CC         hypoxanthine; Xref=Rhea:RHEA:25904, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:17368, ChEBI:CHEBI:58863, ChEBI:CHEBI:58864;
CC         EC=3.2.2.26; Evidence={ECO:0000256|HAMAP-Rule:MF_00991};
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00991}.
CC   -!- SIMILARITY: Belongs to the PNP/UDP phosphorylase family.
CC       Futalosine hydrolase subfamily. {ECO:0000256|HAMAP-Rule:MF_00991}.
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DR   EMBL; CP000820; ABW09619.1; -; Genomic_DNA.
DR   RefSeq; WP_012157596.1; NC_009921.1.
DR   STRING; 298653.Franean1_0152; -.
DR   EnsemblBacteria; ABW09619; ABW09619; Franean1_0152.
DR   KEGG; fre:Franean1_0152; -.
DR   eggNOG; ENOG4108UIH; Bacteria.
DR   eggNOG; COG0775; LUCA.
DR   HOGENOM; HOG000019418; -.
DR   KO; K11783; -.
DR   OMA; EMDRNLG; -.
DR   OrthoDB; 1860206at2; -.
DR   BioCyc; FSP298653:G1G9X-150-MONOMER; -.
DR   UniPathway; UPA00079; -.
DR   Proteomes; UP000001313; Chromosome.
DR   GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:UniProtKB-UniRule.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   HAMAP; MF_00991; MqnB; 1.
DR   InterPro; IPR019963; FL_hydrolase_MqnB.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF53167; SSF53167; 1.
DR   TIGRFAMs; TIGR03664; fut_nucase; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8LCI0.
DR   SWISS-2DPAGE; A8LCI0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001313};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
KW   Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_00991};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001313}.
FT   DOMAIN       62    291       PNP_UDP_1. {ECO:0000259|Pfam:PF01048}.
SQ   SEQUENCE   313 AA;  31532 MW;  F0BC5D7203D4744B CRC64;
     MTRTLIVTAV NAEADAVCAG LMGSWSRGRS RTPSGPGGLV SPDWDRQLLT TSTLGPYVGR
     RRGPVTVLAA GPAGPASAAG TAVALAVASA AGEPFGLVIS MGIAGGFRGW AEVGDLVIAD
     RMVAADLGAE SGLDEPAEPA APVRINEMDR NLGFHPAGAP PYQPGPPPGP VAAGAFLTMD
     DLGLGSSTLQ PDADLVRRLT TVLDITGRRI VSGTVLTVST VTGTERRAAA LTARLDPVAE
     AMEGYAVGIA AGAFGVPVTE IRAVSNPVGR RDRAAWNTQA ALGSLRTAAA ALVAHPEGLV
     PAPRAEKESG PTG
//

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