(data stored in ACNUC7421 zone)

SWISSPROT: A8LCL1_FRASN

ID   A8LCL1_FRASN            Unreviewed;       418 AA.
AC   A8LCL1;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   RecName: Full=Glutamate dehydrogenase {ECO:0000256|PIRNR:PIRNR000185};
GN   OrderedLocusNames=Franean1_0183 {ECO:0000313|EMBL:ABW09650.1};
OS   Frankia sp. (strain EAN1pec).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW09650.1, ECO:0000313|Proteomes:UP000001313};
RN   [1] {ECO:0000313|Proteomes:UP000001313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EAN1pec {ECO:0000313|Proteomes:UP000001313};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
CC       {ECO:0000256|PIRNR:PIRNR000185, ECO:0000256|RuleBase:RU004417}.
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DR   EMBL; CP000820; ABW09650.1; -; Genomic_DNA.
DR   RefSeq; WP_012157627.1; NC_009921.1.
DR   STRING; 298653.Franean1_0183; -.
DR   EnsemblBacteria; ABW09650; ABW09650; Franean1_0183.
DR   KEGG; fre:Franean1_0183; -.
DR   eggNOG; ENOG4107R37; Bacteria.
DR   eggNOG; COG0334; LUCA.
DR   HOGENOM; HOG000243801; -.
DR   KO; K00261; -.
DR   OMA; GSHGRES; -.
DR   OrthoDB; 1184827at2; -.
DR   BioCyc; FSP298653:G1G9X-181-MONOMER; -.
DR   Proteomes; UP000001313; Chromosome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0016639; F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   CDD; cd01076; NAD_bind_1_Glu_DH; 1.
DR   InterPro; IPR006095; Glu/Leu/Phe/Val_DH.
DR   InterPro; IPR006096; Glu/Leu/Phe/Val_DH_C.
DR   InterPro; IPR006097; Glu/Leu/Phe/Val_DH_dimer_dom.
DR   InterPro; IPR014362; Glu_DH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR033922; NAD_bind_Glu_DH.
DR   Pfam; PF00208; ELFV_dehydrog; 1.
DR   Pfam; PF02812; ELFV_dehydrog_N; 1.
DR   PIRSF; PIRSF000185; Glu_DH; 1.
DR   PRINTS; PR00082; GLFDHDRGNASE.
DR   SMART; SM00839; ELFV_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8LCL1.
DR   SWISS-2DPAGE; A8LCL1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001313};
KW   NAD {ECO:0000256|PIRSR:PIRSR000185-2};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000185-2};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000185,
KW   ECO:0000256|RuleBase:RU004417};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001313}.
FT   DOMAIN      184    415       ELFV_dehydrog. {ECO:0000259|SMART:
FT                                SM00839}.
FT   ACT_SITE    107    107       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000185-1}.
FT   BINDING      71     71       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000185-2}.
FT   BINDING      95     95       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000185-2}.
FT   BINDING     191    191       NAD. {ECO:0000256|PIRSR:PIRSR000185-2}.
FT   BINDING     351    351       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000185-2}.
FT   SITE        147    147       Important for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR000185-3}.
SQ   SEQUENCE   418 AA;  44547 MW;  A50BF63A54C3D027 CRC64;
     MILGTGSAWD TACVQLADAA QHLGLDDGMH DLLRTPRRSI TVSVPLLRDD GQLLVLSGYR
     VQHNLARGPA KGGLRYHPAC DLDEVKALAM WMTWKCALMG IPYGGAKGGI AVEPGLLSRQ
     ERERMTRRYA AELVPLIGPD KDIPAPDVGT DEQTMAWIMD TYSTHTGHTA PGVVTGKPLS
     IGGSAGRAGA TSRGVQLAAF AALRELGRDP RETTVAVQGF GKVGALAAQY LHDAGCRLVA
     VSDVKGGIHN RAGLNPSALI RHLARGADTV VGYPGTDTIT NTELLELNVD MLVPAALEGV
     INTGNADRVR APLIVEGANG PVTAEADHVL TGKGTVIVPD ILANGGGVAV SYFEWVQDIQ
     AYFWTEDQVN DRLRALMQRS YQEVSALARE RRVSLRTAAH IIGVARVAEA HRTRGLYP
//

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