(data stored in ACNUC7421 zone)

SWISSPROT: A8LF29_FRASN

ID   A8LF29_FRASN            Unreviewed;       709 AA.
AC   A8LF29;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   RecName: Full=Thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN   OrderedLocusNames=Franean1_0308 {ECO:0000313|EMBL:ABW09774.1};
OS   Frankia sp. (strain EAN1pec).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW09774.1, ECO:0000313|Proteomes:UP000001313};
RN   [1] {ECO:0000313|Proteomes:UP000001313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EAN1pec {ECO:0000313|Proteomes:UP000001313};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-
CC       Rule:MF_00165}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165, ECO:0000256|SAAS:SAAS01114966};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS01070220}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00165}.
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DR   EMBL; CP000820; ABW09774.1; -; Genomic_DNA.
DR   STRING; 298653.Franean1_0308; -.
DR   EnsemblBacteria; ABW09774; ABW09774; Franean1_0308.
DR   KEGG; fre:Franean1_0308; -.
DR   eggNOG; ENOG4108ZMD; Bacteria.
DR   eggNOG; COG0125; LUCA.
DR   HOGENOM; HOG000022435; -.
DR   KO; K00943; -.
DR   OMA; DRRWTMV; -.
DR   Proteomes; UP000001313; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06174; MFS; 1.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   InterPro; IPR010290; TM_effector.
DR   Pfam; PF05977; MFS_3; 1.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8LF29.
DR   SWISS-2DPAGE; A8LF29.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070209};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001313};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070206, ECO:0000313|EMBL:ABW09774.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070211};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070205};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001313};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070204, ECO:0000313|EMBL:ABW09774.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     29     51       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     63     86       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    106    134       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    196    215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    248    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    282    302       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    314    332       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    338    360       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    372    395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    415    435       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      473    613       Thymidylate_kin. {ECO:0000259|Pfam:
FT                                PF02223}.
SQ   SEQUENCE   709 AA;  74895 MW;  04CA59D20E9F297D CRC64;
     MPSPPRARTT GGSDGDLRAV LRIPEFRRMW IQLSLSSLGD WMGLLATTAL VTQLTESFSG
     QAFAISSLLI VRLLPALVLG PLAGAIADRL DRRMTMVITD VMRFGLFLSI PIVGTLGWLL
     IASFLVECVS LVWAPAKEAS IPHLVPRNRL AAANTLSLIT TYGTAPLAAA IFTLLATVSR
     ALGPSIHFFR DSSLDIALYF NAATFLGSAI VIWGLRSIGR AERPEHSTEP GFFASITEGW
     KFVGQDRLVR GLVVGILGGF AGAGCVVALG KLYVEILGGG DSAYGVLFGA VFIGLAAGMG
     AGPKLLGDYS RTRLFGVCVT AAGITLVVVA IIPNLVIACI LVVFVGALAG VAWVTGYTLL
     QAEVADELRG RTFALVQSLV RVDLLVVLAA APALVGLIGS HQVHLWGDIN VRADGVTVVL
     LAGGLLAVAV GLFSYRQMDD HTGEAVLPEL WNALRGRRPG TARRRHGGLF ITVEGAAGAG
     KTTQLELLRS WLSSSGREVV PAYETDGTSL GAGLRDLLDD PANRLHARTE LLLDAADRAE
     HVARVIEPAL ARGAIVLTDR YVDSAIACQA LGQRIDSDEL TVLTQWASHS LLPDVTILLD
     LPAEQALARG GSDPHLGRES EGDGSGHDGG AGRGGGAGHG AGPDRSGTDP VAAVAYHRRV
     REHFRRLADE DPDRHVILDA TLSPQELHRQ IRAVIAGRLR PAITGDDPR
//

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